Abstract: Objective:To explore the qualitative diagnosis value of the color Doppler ultrasound combined with ultrasonic elastography on breast masses.Methods:One hundred and fifty-six patients with breast mass(174 masses) were detected using the color Doppler flow imaging combined with ultrasonic elastography,the result of which was compared with pathological findings.The sensitivity,specificity and accuracy in diagnosing malignant breast tumor between the combined detection of two methods and single method detection were compared.Results:The sensitivity,specificity and accuracy of the color Doppler ultrasound in the diagnosis of malignant breast tumor were 82.1%,72.6% and 78.7%,respectively.The sensitivity,specificity and accuracy of ultrasonic elastography in the diagnosis of malignant breast tumor were 84.8%,74.4% and 80.5%,respectively.The sensitivity,specificity and accuracy of the color Doppler ultrasound combined with ultrasonic elastography in the diagnosis of malignant breast tumor were 88.4%,91.9% and 89.7%,respectively.The difference of the detection result between the color Doppler ultrasound combined with ultrasonic elastography and pathological examination was not statistically significant(P>0.05).Conclusions:The detection of color Doppler ultrasound combined with ultrasonic elastography can effectively diagnose the malignant breast masses,which is an effective mean in early diagnosis of breast disease.