早期帕金森病病人嗅觉障碍的相关性分析

檀国祥; 许啟伍; 丁婷; 李其英

doi:10.13898/j.cnki.issn.1000-2200.2017.03.017

早期帕金森病病人嗅觉障碍的相关性分析

The correlative analysis of the olfactory dysfunction in patients with early stage Parkinson's disease

摘要

摘要: 目的：检测早期帕金森病（PD）病人嗅觉功能障碍情况，探讨嗅觉定量检测在早期PD诊断中的意义。方法：选取早期PD病人45例及同期健康成人49名（对照组）作为研究对象，应用“五味嗅觉测试液”进行双侧鼻孔嗅觉检测，并评价PD病人年龄、病程、统一PD评定量表（UPDRS）评分、Hoehn-Yahr（H-Y）分级与嗅觉的相关性。结果：PD病人的嗅觉察觉阈值及识别阈值均明显高于对照组（P<0.01），嗅觉察觉阈值及识别阈值与病人年龄、病程、UPDRS评分、H-Y分级均无明显相关关系（P>0.05），UPDRS评分与病程、H-Y分级均呈正相关关系（P<0.05和P<0.01）。结论：早期PD病人存在嗅觉功能障碍，且双侧对称性出现，嗅觉检测对早期诊断PD有一定意义。

Abstract: Objective:To detect the olfactory dyfunction condition in patients with early stage Parkinson's disease,and explore the significance of the quantitative olfactory detection in the early diagnosis of PD.Methods:The bilateral nasal olfactory in 45 patients with early stage PD and 49 healthy examinees at the same time were examined using the "five odors olfactory detection arrays".The relationships between the age,disease duration,UPDRS score and Hoehn-Yahr staging,and olfactory were analyzed in patients with PD.Results:The detection threshold and identification threshold of olfactory in patients with Parkinson's disease were significantly higher than those in healthy people(P<0.01).The detection threshold and identification threshold of olfactory were not signficantly correlated with the age,course of disease,UPDRS score and Hoehn-Yahr staging of patients(P>0.05),and the UPDRS score was positively correlated with the disease duration and H-Y staging(P<0.01 and P<0.05).Conclusions:The olfactory dysfunction in patients with early stage PD is found,and bilateral symmetry.The olfactory detection has certain significance in the early diagnosis of PD.

HTML全文

参考文献(15)

施引文献

资源附件(0)