Abstract: Objective:To investigate the effects of adefovir dipivoxil(ADV) combined with Hujuyigan capsule in the treatment of liver fibrosis in chronic hepatitis B(CHB).Methods:Sixty-five CHB patients were divided into the observation group and control group according to the number of parity.The control group were treated with ADV by oral,and the observation group were additionally treated with Hujuyigan capsule based on the control group.The ALT recovery rate,HBeAg and HBV DNA converting negative rates,hepatic fibrosis indexes and immune function in two groups were observed before and after treatment.Results:Six months after treatment,the differences of the ALT recovery rate,and HBeAg and HBV DNA converting negative rates between two groups were not statistically significant(P>0.05).Compared with the control group,the hepatic fibrosis indexes in observation group significantly decreased(P<0.01).Compared with the control group,the expression of Ⅰ γ interferon in observation group was obviously up-regulated,and the expressions of tumor necrosis factor α and interleukin-4 were inhibited(P<0.01).Conclusions:The curative efficacy of Hujuyigan capsule and ADV in treating CHB is significant,which is worthy of popularization and application.