Abstract: Objective:To investigate the clinical efficacy of Tongfu Huatan Decoction combined with western medicine in the treatment of chronic obstructive pulmonary disease in acute exacerbation(AECOPD).Methods:Eighty patients with AECOPD were divided into the control group and observation group using random number table method(40 cases each group).The control group and observation group were treated with routine western medicine and Tongfu Huatan Decoction combined with routine western medicine for two weeks(1 course),respectively.The clinical efficacy,lung function,6 min walking test results and changes of inflammatory markers between two groups were compared.Results:The total effective rate in observation group(95.0%) was higher than that in control group(72.5%)(P<0.05).After treatment,the lung function indictors in observation group were higher than those in control group(P<0.01),the 6 min walk distance in observation group(325.4±24.2)m was longer than that in control group(277.6±21.5)m(P<0.01).After treatment,the level of superoxide dismutase in peripheral blood in observation group was higher than that in control group,and the levels of lipid peroxide,white blood count and C-reactive protein in observation group were lower than those in control group(P<0.05 to P<0.01).Conclusions:Tongfu Huatan Decoction can improve the therapeutic effects of western medicine on AECOPD,which is worthy of promotion.