Abstract: Objective:To investigate the diagnostic value of the prenatal ultrasound for fetal limb malformation within 14 weeks of pregnancy.Methods:One thousand nine hundred and seventy early pregnancy women from May 2013 to May 2015 were investigated.The pregnant women were examined using ultrasound at 14 weeks and 24 weeks of pregnancy,and the morphology,structure,posture and movement of fetuses were observed using the systematic continuous sequence approach.The newborn was regularly followed up,and the autopsy of the fetus corpse after induced labor was implemented.Results:The ultrasonography of all fetal limbs was clear.The limb malformation in 20 cases,missed diagnosis of fetal limb deformity in 9 cases and misdiagnosis of congenital clubfoot in 1 case were identified,and the detection rate of fetus limb malformation was 68.9%(20/29) in early pregnancy.The fetal limb deformity in 6 cases and correcting the misdiagnosis of early pregnancy in 1 case were found in the second detection,the detection rate of two times in fetus limb malformation was 89.7%(26/29).In the early pregnancy detection of fetal limb malformation,the fetal limb malformation complicated with nasal bone loss in 3 cases,neck hygroma in 3 cases,and nuchal translucency thickening and venous flow spectrum change in 37.9%(11/29) fetuses were found.Conclusions:Most severe fetal limb deformities can be diagnosed by ultrasonography in time,which can make a correct guidance to implement effective intrauterine treatment or induction of labor.