Abstract: Objective: To investigate the correlations between the serum levels of homocysteine(Hcy),hypersensitive C-reactive protein(hs-CRP) and degree of coronary artery atherosclerosis in patients with coronary heart disease(CHD).Methods: One hundred and twenty-eight patients suspected or diagnosed with CHD were divided into the single branch lesion group(33 cases),double branch lesions group(32 cases),three branch lesions group(29 cases) and non-CHD group(34 cases) according to the results of coronary arteriography.The levels of Hcy and hs-CRP between four groups were compared.Results: With the increasing of branch of coronary lesions,the levels of Hcy and hs-CRP increased.The ratio of high Hcy in patients with two and three branch lesions was higher than that in patients with single branch or non-CHD patients(P<0.01).The level of Hcy was positively correlationed with the level of hs-CRP in CHD patients(P<0.05).Conclusions: With the increasing of branch of coronary lesions,the levels of Hcy and hs-CRP increase,and the level of Hcy is correlated with the level of hs-CRP.The mechanism of Hcy aggravating the coronary artery atherosclerosis may be related with inflammatory reaction.