Abstract: Objective: To explore the teaching effects of problem-based learn(PBL) in postgraduate education of emergency medicine in the era of precision medicine.Methods: Twenty-three postgraduates of emergency medicine in Bengbu Medical College were divided into the observation group(13 students) and control group(10 students).The observation group and control group were taught using PBL and lecture-based learning,respectively.The comprehensive examination and questionnaire were used to evaluate the teaching effects of PBL.Results: The examination scores of clinical thinking ability,clinical skill proficiency,problem-solving ability and total score in observation group were significantly better than those in control group(P<0.05).The learning interest,autonomous learning ability,analyzing problem ability,solving problem ability,clinical thinking ability,scientific research innovation ability,communication ability and teamwork ability in observation group were significantly higher than those in control group(P< 0.05 to P< 0.01).Conclusions: The application of PBL in postgraduate education of emergency medicine can effectively improve the leading role of teacher and subject role of student,fully mobilize the learning knowledge desire,cultivate the scientific research innovation awareness,teamwork ability and clinical problem-solving ability.