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    苏玉璇, 张伊莉, 卞建军, 左金曼. 重组人血小板生成素不同给药频率治疗急性白血病化疗后血小板减少症的疗效和安全性观察[J]. 蚌埠医科大学学报, 2017, 42(7): 899-900,903. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.019
    引用本文: 苏玉璇, 张伊莉, 卞建军, 左金曼. 重组人血小板生成素不同给药频率治疗急性白血病化疗后血小板减少症的疗效和安全性观察[J]. 蚌埠医科大学学报, 2017, 42(7): 899-900,903. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.019
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    SU Yu-xuan, ZHANG Yi-li, BIAN Jian-jun, ZUO Jin-man. The efficacy and safety of different dosing frequency rhTPO in the treatment of postchemotherapy thrombocytopenia in acute leukemia patients[J]. Journal of Bengbu Medical University, 2017, 42(7): 899-900,903. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.019
    Citation: SU Yu-xuan, ZHANG Yi-li, BIAN Jian-jun, ZUO Jin-man. The efficacy and safety of different dosing frequency rhTPO in the treatment of postchemotherapy thrombocytopenia in acute leukemia patients[J]. Journal of Bengbu Medical University, 2017, 42(7): 899-900,903. DOI: 10.13898/j.cnki.issn.1000-2200.2017.07.019
    shu

    重组人血小板生成素不同给药频率治疗急性白血病化疗后血小板减少症的疗效和安全性观察

    The efficacy and safety of different dosing frequency rhTPO in the treatment of postchemotherapy thrombocytopenia in acute leukemia patients

      摘要
    • 摘要: 目的：评价重组人血小板生成素（rhTPO）不同给药频率治疗急性白血病化疗后血小板（PLT）减少症病人的疗效和安全性。方法：选取急性白血病化疗后PLT减少症病人40例，随机分为2组。A组为连续给药，给予rhTPO 15 000 U，每日1次，用药14次；B组为隔天给药，给予rhTPO 15 000 U，隔日1次，用药7次。比较2组病人的疗效并观察不良反应发生情况。结果：治疗后A组病人PLT水平明显高于B组（P<0.01），A组病人PLT<50×109/L的持续时间及恢复至75×109/L、100×109/L所需的时间均明显少于B组（P<0.01）；所有纳入最后疗效评估的病人均未出现严重不良事件。结论：rhTPO连续给药比隔日给药对白血病化疗后病人PLT水平有更好的提升作用；在降低出血风险和用药安全性方面，rhTPO 2种给药方案无明显差别。

       

      Abstract: Objective:To evaluate the efficacy and safety of different dosing frequency recombinant human thrombopoietin(rhTPO) in the treatment of postchemotherapy thrombocytopenia in acute leukemia patients.Methods:Forty acute leukemia patients complicated with thrombocytopenia were randomly divided into the group A and group B.The group A were contiously treated with 15 000 U rhTPO,one time a day for 14 times,and the group B were treated with 15000 U rhTPO,one time two days for 7 times.The clinical effects and adverse reactions between two groups were compared.Results:After treatment,the level of platelet(PLT) in group A was significantly higher than that in group B(P<0.01).The duration time of PLT<50×109/L,and the recovery time of PLT from 50×109/L arriving at 75×109/L or 100×109/L in group A were significantly less than those in group B(P<0.01).No serious adverse events occurred in two groups.Conclusions:Compared with alternate-day dosing,the continuous dosing plays better enhancing effect in the PLT level.The difference of the reducing the risk of bleeding and medication safety between two groups is not obvious.

       

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