Abstract: Objective:To observe the effects of the respiratory care management in the prevention of pulmonary infection in hepatic failure patients.Methods:One hundred and fifty-two patients with hepatic failure were divided into the prevention group and conventional group using a random number table method(76 cases each group).The prevention group were nursed with the additional staff responsible for respiratory care based on the routine nursing,and the nursing standard of care measure was formulated for all-round monitoring.The related mortality rate,lung infection rate,average length of hospital stay and consumption between two groups were compared.Results:Among the patients with lung infection,the ratio of related-infection death in prevention group and conventional group were 38.89% and 50.00%,respectively,and the difference of which was not statistically significant(P>0.05).Among all patients,the ratio of related-infection death in prevention group(9.21%) was significantly lower than that in conventional group(23.69%)(P<0.01).The lung infection rate in prevention group(23.68%) was significantly lower than that in conventional group(47.37%)(P<0.01).The length of hospital stay and cost in prevention group were less than those in conventional group(P<0.01).Conclusions:The respiratory care can prevent the lung infection,reduce infection and mortality rates,and shorten the hospitalization time and cost in patients with hepatic failure.