Abstract: Objective: To study the related risk factors of contrast-induced nephropathy(CIN) of acute myocardial infarction(AMI) patients treated with percutaneous coronary intervention(PCI).Methods: One hundred and ten patients with AMI were treated with PCI,and divided into the CIN group and non-CIN group.The general information,underlying diseases,premedication and dosage of contrast agent between two groups were compared,and the risk factors of CIN were analyzed.Results: The differences of the gender,age,body mass index,blood sugar level,dyslipidemia,hypertension,myocardial infarction and cerebral infarction between two groups were not statistically significant(P>0.05).The differences of the renal insufficiency,diabetes,anemia,SCr,hs-CRP,eGFR,LVEF,CK and CMV between two groups were statistically significant(P<0.05 to P<0.01).The renal insufficiency,SCr,eGFR,CMV,CMV/eGFR,hs-CRP,LVEF,diabetes and anemia were the independent influencing factors of CIN(P<0.05 to P<0.01).Conclusions: The renal insufficiency and large dose of contrast agent are the risk factors of CIN,and the diabetes,high hs-CRP and CMV/eGFR also need to cause enough attention among the risk factors of CIN.