Abstract: Objective: To investigate the clinical effects of one-stage combined with anterior and posterior approach in the treatment of lumbar nonspecific infection.Methods: Twelve patients with lumbar nonspecific infection were treated with one stage posterior pedicle screw fixation,scavenging the infection and intervertebral autogenous bone graft.The patients were treated with antibiotics for 6 to 12 weeks,and the antibiotics did not be used until the levels of erythrocyte sedimentation rate(ESR) and C reactive protein(CRP) recovered normal after 2 to 4 weeks of treatment.The levels of ESR and CRP before operation and after 1,2 and 3 months of operation were compared.Results: After operation,the symptoms of the patients were improved significantly,the incision of 12 cases were first rate healing,and there were no formation of sinus tract and fistula,and recurrence of infection.The following-up time was 18 to 30 months,all bone grafts were solid bony fusion,and no obvious vertebral body collapse and pseudarthrosis were found after 5 to 7 months of operation.The levels of CRP of patients before operation and after 1,2 and 3 months of operation were lower than that in the outpatient treatment(P<0.05 to P<0.01),and the levels of ESR of patients after 1,2 and 3 months of operation were lower than that in the outpatient treatment and before opertaion(P<0.01).Conclusions: The clinical effect of one stage posterior pedicle screw fixation,scavenging the infection and intervertebral autogenous bone graft is obvious,which can avoid the infected lesions,reduce the potential risk of infection recurrence and promote the recovery of illness,and is an effective method.