Abstract: Objective: To investigate the effects of job insecurity,quality of work life and organization atmosphere on the turnover intention of nurses.Methods: Four hundred and ninety-five nurses were investigated using the general information questionnaire,turnover intention scale,job insecurity scale,organizational atmosphere scale and quality of work life scale,and the correlation analysis and structural equation model of which was constructed.Results: The correlation analysis and recursive model showed that the nurse organization atmosphere,quality of working life,job insecurity and turnover intention were significant correlation(P<0.01).Job insecurity positively predicted the turnover intention of nurses,and the organizational atmosphere and quality of life negatively predicted the turnover intention of nurses.The quality of work life played partial mediation effect in between the job insecurity and turnover intention,and the organizational atmosphere played partial mediation effect in between the quality of working life and turnover intention.Job insecurity and quality of life were explained the 43% of the variance of organization atmosphere,and the job insecurity,organizational atmosphere and quality of work life could explain the 19% of the joint internal variance of turnover intention.Conclusions: Job insecurity,quality of work life and organizational atmosphere are the antecedent variables of turnover intention..Hospital and nursing administrators should pay attention to the job insecurity of nurses,construct the harmonious atmosphere,and improve the quality of work life to stabilize the team of nurses.