纤溶酶对非ST段抬高性心肌梗死非手术治疗病人炎性因子的干预研究

沙莎

doi:10.13898/j.cnki.issn.1000-2200.2017.10.016

纤溶酶对非ST段抬高性心肌梗死非手术治疗病人炎性因子的干预研究

沙莎

Effect of fibrinolytic enzyme on inflammatory factors in non-ST-segment elevation myocardial infarction patients

SHA Sha

摘要

摘要: 目的：纤溶酶对非ST段抬高性心肌梗死非手术治疗病人炎性因子表达的影响。方法：选择符合非ST段抬高性心肌梗死诊断标准但未行冠脉介入治疗的病人80例（治疗组）及体检正常者40名（对照组）作为研究对象，观察2组血清炎性标志物高敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6）的表达，再将80例非ST段抬高性心肌梗死病人随机分为常规治疗组和纤溶酶治疗组，观察纤溶酶对非ST段抬高性心肌梗死非手术治疗病人炎性标志物hs-CRP、TNF-α、IL-6表达的影响。结果：入院时，观察组较对照组血清hs-CRP、TNF-α、IL-6明显升高（P<0.01）。治疗后，纤溶酶治疗组较常规治疗组血清hs-CRP、TNF-α、IL-6明显降低（P<0.01）。结论：非ST段抬高性心肌梗死涉及免疫炎症损伤，纤溶酶可以抑制免疫炎症因子表达。

Abstract: Objective:To investigate the effects of fibrinolytic enzyme on inflammatory factors in non-surgical patients with non-ST-segment elevation myocardial infarction.Methods:Eighty patients with non-ST-segment elevation myocardial infarction and normal physical examinees were divided into the treatment group and control group,respectively.The serum levels of high-sensitivity c-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α) and interleukin 6(IL-6) in two groups were observed.Eighty patients with non-ST-segment elevation myocardial infarction were randomly subdivided into the routine treatment group and fibrinolytic enzyme treatment group,and the effects of fibrinolytic enzyme on the levels of hs-CRP,TNF-α and IL-6 were observed.Results:Compared with the control group,the serum levels of hs-CRP,TNF-α and IL-6 in observation group at admission significantly increased(P<0.01).After treatment,the serum levels of hs-CRP,TNF-α and IL-6 in fibrinolytic enzyme treatment group significantly decreased compared with the routine treatment group(P<0.01).Conclusions:The non-ST-segment elevation myocardial infarction involves the immune inflammatory injury,and fibrinolytic enzyme can inhibit the expression of immune inflammatory factors.

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