• 中国科技核心期刊
  • 中国科技论文统计源期刊
  • 安徽省优秀科技期刊
  • 中国高校优秀期刊

黄芪地黄汤联合环磷酰胺治疗难治性肾病综合征的疗效及安全性评价

项红秀

项红秀. 黄芪地黄汤联合环磷酰胺治疗难治性肾病综合征的疗效及安全性评价[J]. 蚌埠医科大学学报, 2017, 42(10): 1365-1367. DOI: 10.13898/j.cnki.issn.1000-2200.2017.10.022
引用本文: 项红秀. 黄芪地黄汤联合环磷酰胺治疗难治性肾病综合征的疗效及安全性评价[J]. 蚌埠医科大学学报, 2017, 42(10): 1365-1367. DOI: 10.13898/j.cnki.issn.1000-2200.2017.10.022
XIANG Hong-xiu. The evaluation of clinical efficacy and safety of Huangqi Dihuang decoction combined with cyclophosphamide in the treatment of refractory nephrotic syndrome[J]. Journal of Bengbu Medical University, 2017, 42(10): 1365-1367. DOI: 10.13898/j.cnki.issn.1000-2200.2017.10.022
Citation: XIANG Hong-xiu. The evaluation of clinical efficacy and safety of Huangqi Dihuang decoction combined with cyclophosphamide in the treatment of refractory nephrotic syndrome[J]. Journal of Bengbu Medical University, 2017, 42(10): 1365-1367. DOI: 10.13898/j.cnki.issn.1000-2200.2017.10.022

黄芪地黄汤联合环磷酰胺治疗难治性肾病综合征的疗效及安全性评价

详细信息
    作者简介:

    项红秀(1971-),女,副主任医师.

  • 中图分类号: R692

The evaluation of clinical efficacy and safety of Huangqi Dihuang decoction combined with cyclophosphamide in the treatment of refractory nephrotic syndrome

  • 摘要: 目的:探讨黄芪地黄汤联合环磷酰胺治疗难治性肾病综合征的临床疗效及安全性。方法:难治性肾病综合征病人96例,按照随机数字表法分为观察组和对照组,各48例。对照组给予环磷酰胺治疗,观察组在对照组基础上联合黄芪地黄汤治疗。2组疗程均为6个月。比较2组病人治疗有效率、治疗前后肾功能指标尿素氮、血肌酐和24 h尿蛋白、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平以及不良反应情况。结果:观察组总有效率95.83%,高于对照组的79.17%(P<0.05);2组治疗后尿素氮、血肌酐、24 h尿蛋白水平和血清IL-6、TNF-α水平均较治疗前明显下降(P<0.01),且观察组相应指标的下降幅度均明显大于对照组(P<0.01);2组病人均无明显药物不良反应。结论:黄芪地黄汤联合环磷酰胺治疗难治性肾病综合征临床疗效确切,且安全性良好,其作用可能与改善肾功能和降低24 h尿蛋白、IL-6和TNF-α水平有关。
    Abstract: Objective:To investigate the clinical efficacy and safety of Huangqi Dihuang decoction combined with cyclophosphamide in the treatment of refractory nephrotic syndrome.Methods:Ninety-six patients with refractory nephrotic syndrome were randomly divided into the observation group and control group(48 cases each group).The control group was treated with cyclophosphamide,and the observation group was treated with Huangqi Dihuang decoction based on the control group for 6 months.The effective rate of treatment,levels of urea nitrogen(BUN),serum creatinine(Scr),24 h urinary protein,interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) before and after treatment,and adverse reactions between the two groups were compared.Results:The total effective rate in observation group(95.83%) was higher than that in control group(79.17%)(P<0.05).Compared with before treatment,the levels of BUN and Scr,24 h urine protein,IL-6 and TNF-α in two groups significantly decreased after treatment (P<0.01),and the decreasing levels of BUN and Scr,24 h urine protein,IL-6 and TNF-α in observation group were significantly lower than those in control group(P<0.01).No obvious adverse drug reactions in two groups were found.Conclusions:Huangqi Dihuang decoction combined with cyclophosphamide in the treatment of refractory nephrotic syndrome is effective and safe,which may be related to the improvement of renal function and decreasing levels of 24 h urinary protein,IL-6 and TNF-α.
  • [1]

    NAKAMURA Y,TAKEHANA Y,ASAKURA T,et al.Analysis of social factors related to better school life in children with refractory nephrotic syndrome[J].Nihon Shoni Jinzobyo Gakkai Zasshi,2014,27(2):119.

    [2] 罗月中,涂海涛.难治性肾病综合征发病机制研究进展[J].广东医学,2010,31(17):2321.
    [3]

    CHEN YX,FENG YY,FANG XD,et al.Tacrolimus and cyclophosphamide in treatment of refractory nephrotic syndrome efficacy and safety:A Meta-analysis[J].Chinese General Practice,2014,17(17):2008.

    [4] 张彦芬,李涛,郭永力.中西医结合治疗难治性肾病综合征疗效观察[J].四川中医,2015,19(3):104.
    [5] 安金龙,周丽娜,张文军,等.中西医结合治疗难治性肾病综合征28例临床观察[J].江苏中医药,2015,47(10):43.
    [6] 郑莜萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:79.
    [7] 刘琳.中西医结合治疗难治性肾病综合征临床研究[J].四川中医,2015,40(7):74.
    [8] 王润才.中西医结合治疗难治性肾病综合征疗效观察[J].实用中医药杂志,2016,32(3):218.
    [9] 尹秀英.中西医结合治疗难治性肾病综合征45例[J].中国中医药现代远程教育,2015,13(23):63.
    [10] 李金刚,许建成.益肾活血汤联合西医治疗难治性肾病综合征随机平行对照研究[J].实用中医内科杂志,2016,30(2):38.
    [11] 郭皓.低分子肝素联合激素、环磷酰胺治疗难治性肾病综合征的疗效观察[J].中国现代医生,2014,52(5):53.
    [12] 金秀名.环磷酰胺冲击联合激素治疗难治性肾病综合征临床分析[J].临床医学,2014,34(1):52.
    [13] 杨敬伟.益气温阳补肾汤治疗难治性肾病综合征疗效及对T淋巴细胞亚群、细胞因子的影响[J].现代中西医结合杂志,2016,13(4):382.
    [14] 王丽雅.来氟米特联合糖皮质激素治疗原发性难治性肾病综合征病人的临床效果及对炎性细胞因子水平的影响[J].中国医药科学,2014,5(11):77.
  • 期刊类型引用(13)

    1. 倪斌. 固本通络汤联合激素及环磷酰胺治疗难治性肾病综合征78例. 中医临床研究. 2021(07): 97-99 . 百度学术
    2. 叶航,张姝媛. 玉屏风散合真武汤加减治疗难治性肾病综合征47例. 安徽医药. 2021(08): 1675-1679 . 百度学术
    3. 李俊. 保真汤加减辅治难治性肾病综合征临床观察. 实用中医药杂志. 2020(05): 650-651 . 百度学术
    4. 张敏,方立明. 积雪草颗粒联合西药治疗慢性肾脏病临床观察. 实用中医内科杂志. 2020(12): 41-43 . 百度学术
    5. 黄科. 难治性肾病综合征治疗进展探讨. 现代养生. 2019(08): 58-59 . 百度学术
    6. 秦洪臣. 霉酚酸酯联合醋酸泼尼松片治疗原发性难治性肾病综合征的临床效果. 河南医学研究. 2019(06): 1070-1071 . 百度学术
    7. 韦良旋,覃其静. 黄芪细辛汤治疗咳嗽变异性哮喘的临床疗效和安全性评价. 世界最新医学信息文摘. 2019(38): 164+166 . 百度学术
    8. 龚章荣. 益肾活血汤联合西医治疗难治性肾病综合征的临床效果观察. 世界复合医学. 2019(04): 92-94 . 百度学术
    9. 甄颖,刘山. 糖皮质激素与环磷酰胺联合应用治疗难治性肾病综合征的疗效评价. 中国医药科学. 2019(23): 61-63 . 百度学术
    10. 范瑞晨,赵瑞萍. 低分子肝素联合用药对难治性肾病综合征疗效评价. 齐齐哈尔医学院学报. 2018(08): 895-896 . 百度学术
    11. 夏松青,李楠,杨国华. 保肾消浊汤治疗儿童难治性肾病综合征39例. 河南中医. 2018(10): 1552-1554 . 百度学术
    12. 吴小平. 环磷酰胺治疗难治性肾病综合征的临床效果以及不良反应观察. 健康之路. 2018(09): 112 . 百度学术
    13. 李玉平,王术凤,梁学军,刘佰洁,陈洪学. 黄芪丹参颗粒治疗慢性肾功能衰竭患者的临床疗效分析. 现代生物医学进展. 2018(20): 3925-3928 . 百度学术

    其他类型引用(1)

计量
  • 文章访问数:  3376
  • HTML全文浏览量:  514
  • PDF下载量:  72
  • 被引次数: 14
出版历程
  • 收稿日期:  2016-07-03

目录

    /

    返回文章
    返回