Abstract: Objective:To investigate the clinical effects of stain endoscope combined with tumor biomarker in early diagnosis of colorectal cancer.Methods:According to Duck's staging,30 patients with stage Duck's A and B colorectal cancer were set as the observation group,and 30 colorectal polyp patients were set as the control group.The gene and protein expressions of carcinoembryonic antigen and Survivin in two groups were detected using RT-PCR and Western blotting,respectively.Results:Among 30 colorectal cancer patients,intramucosal adenocarcinom in 8 cases and adenocarcinoma in 22 cases were found,and stage Duck's A in 12 cases and stage Duck's B in 18 cases were identified after operation.The expression rates of carcinoembryonic antigen and Survivin at stage Duck's A were 25.00% and 27.78%,and the expression rates of carcinoembryonic antigen and Survivin at stage Duck's B were 41.67% and 55.56%.Among 30 polyp patients,canalicular adenoma in 22 cases,villous adenoma in 6 cases and tubulovillous adenoma in 2 cases were found.The expressions of carcinoembryonic antigen and Survivin in control group were not found,which was lower than that in observed group(P<0.05 to P<0.01).The expression rate of Survivin in observed group was significantly higher than that of carcinoembryonic antigen(P<0.01).Conclusions:The Survivin expression is high in early stage of colorectal cancer,which can set as a potential biomarker in combing with stain endoscope,and has important significance in the early diagnosis and treatment of colorectal cancer.