依达拉奉对慢性阻塞性肺疾病伴认知功能障碍病人的疗效评价

戈艳蕾; 刘聪辉; 崔紫阳; 付爱双; 李立群; 樊蕴辉; 张嘉宾; 张盼盼; 王红阳; 胡玲玲

doi:10.13898/j.cnki.issn.1000-2200.2018.01.011

依达拉奉对慢性阻塞性肺疾病伴认知功能障碍病人的疗效评价

Effect of edaravone on patients with chronic obstructive pulmonary disease complicated with cognitive dysfunction

摘要

摘要: 目的：探讨依达拉奉对慢性阻塞性肺疾病（COPD）合并知功能障碍病人的治疗效果。方法：将208例COPD合并认知功能障碍病人采用随机数字表法分为常规治疗组和依达拉奉组（依达拉奉联合常规治疗）。比较2组病人治疗前后的蒙特利尔认知评估量表（MoCA量表）评分、总体治疗效果及在意向治疗人群（ITT人群）与符合方案人群（PP人群）中2组病人治疗总有效率变化情况。结果：治疗后2组病人MoCA量表评分均较治疗前改善，且依达拉奉组改善更为显著（P<0.05）；依达拉奉组总体治疗效果优于常规治疗组（P<0.05）；ITT人群与PP人群中2组治疗总有效率差异均无统计学意义（P>0.05）。结论：依达拉奉可改善COPD伴认知功能障碍病人的认知功能，提高临床治疗效果。

Abstract: Objective:To investigate the effects of edaravone on patients with chronic obstructive pulmonary disease(COPD) complicated with cognitive dysfunction.Methods:Two hundred and eighteen patients with COPD complicated with cognitive dysfunction were randomly divided into the edaravone group(treated with edaravone combined with routine treatment) and routine treatment group.The MoCA scores,total treatment effect and effective rates in intent to treat population(ITT population) and per protocol population(PP population) between two groups before and after treatment were compared.Results:After treatment,the MoCA scores in two groups were significantly improved,especially for the edaravone group(P<0.05).The total treatment effect in edaravone group was better than that in routine treatment group(P<0.05).The difference of the effective rate between ITT population and PP population was not statistically significant(P>0.05).Conclusions:Edaravone can improve the cognitive function,and enhance the curative effect in patients with COPD complicated with cognitive impairment,

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