Abstract: Objective:To investigate the influences of analgesic effect and sevoflurane anesthesia on the serum levels of ALT and AST,in cirrhosis patients treated with partial hepatectomy.Methods:Eighty cirrhotic patients were randomly divided into the sevoflurane anesthesia group(sevoflurane group,n=40) and propofol infusion anesthesia group(propofol group,n=40) according to the random number table.The serum levels of ALT and AST,and analgesic effects in two groups were statistically analyzed.Results:The spontaneous breathing recovery time,opening eye time and extubation time in sevoflurane group were significantly shorter than those in propofol group(P<0.01).The intranperative consumption amount of anesthetic drug per hour,maintaining cost and anesthetic drug cost in sevoflurane group were significantly lower than those in propofol group(P<0.01).The serum levels of ALT and AST in two groups significantly increased after operation(P<0.01),the differences of the serum levels of ALT and AST between two groups were not statistically significant after operation(P>0.05),and the VAS score in two groups significantly decreased after operation(P<0.01),and the VAS score in sevoflurane group was lower than that in propofol group after operation(P<0.01).Conclusions:The sevoflurane anesthesia do not increase the serum levels of ALT and AST and injure the liver in cirrhosis patients treated with partial hepatectomy,and the analgesic effect of which is good.