Abstract: Objective: To investigate the clinical effects of the mini-implant anchorage in orthodontic treatment.Methods: Eighty-four patients with orthodontic treatment were randomly divided into the control group and observation group.The control group and observation group were treated with conventional method and mini-implant anchorage,respectively.Results: After treatment,the back tooth grinding displacement and upper incisor inclination difference in observation group were significantly less than those in control group(P<0.01),and the gnashing of teeth protruding length difference in observation group was significantly more than that in control group(P<0.01).After treatment,the measure value of the upper and lower of jaw and improvement of eigenvalue of upper and lower of jaw in observation group were better than those in control group(P<0.05 to P<0.01).The chewing efficiency and bite force in observation group were significantly better than those in control group(P<0.01).The incidence rates of soft tissue edema and discomfort in observation group were lower than those in control group(P<0.05 and P<0.01).Conclusions: The mini-implant anchorage in orthodontic treatment has important clinical value,the incidence rate of adverse reactions is low,and which is worthy of clinical promotion.