鼠神经生长因子对老年带状疱疹后遗神经痛病人的疗效评价

蓝丽康; 瞿砚舟; 吕锦; 雷四英

doi:10.13898/j.cnki.issn.1000-2200.2018.03.017

鼠神经生长因子对老年带状疱疹后遗神经痛病人的疗效评价

Effect of mouse nerve growth factor in the treatment of post-herpetic neuralgia

摘要

摘要: 目的：探讨鼠神经生长因子（mNGF）治疗老年带状疱疹后遗神经痛（PHN）病人的临床疗效。方法：将老年PHN病人50例，随机分成观察组和对照组，各25例，对照组予维生素B₁₂ 500 μg，每天1次；观察组予mNGF 20 μg肌内注射，每天1次；2组疗程均14 d。2组病人治疗前后，均采用疼痛视觉模拟评分法（VAS）进行评分，评估疗效，并记录不良反应。结果：观察组VAS评分显著低于对照组（P<0.01），总有效率、疼痛减轻程度和疼痛消失时间均明显优于对照组（P<0.01）。结论：采用mNGF治疗PHN安全有效。

Abstract: Objective:To investigate the clinical efficacy and safety of mouse nerve growth factor(mNGF) in the treatment of post-herpetic neuralgia(PHN) in old patients.Methods:Fifty old patients with PHN were randomly divided into the observation group(n=25) and control group(n=25).The observation group were treated with 20 μg mNGF by intramuscular injection once a day,and the control group were treated with 500 μg vitamin B₁₂ once a day for 14 days.The clinical efficacy in two groups were evaluated using visual analogue scale before and after treatment,and the adverse action in two groups were recorded.Results:The VAS score of the observation group was significantly lower than that of the control group(P<0.01).The total effective rate,degree of pain relief and pain disappear time in observation group were significantly better those in control group(P<0.01).Conclusions:mNGF in the treatment of PHN was effective and safe.

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