高级检索

    不同潮气量的机械通气对老年肺癌病人术后的影响

    Effect of the different tidal volume of mechanical ventilation on postoperative old patients with lung cancer

      摘要
    • 摘要: 目的：探索不同潮气量的机械通气对老年肺癌病人手术后的影响。方法：选择老年肺癌手术病人100例，根据病人采用机械通气潮气量的不同分为6 mL/kg组（A组）、8 mL/kg组（B组）和10 mL/kg（C组），分析比较3组病人术后血气分析指标、相关炎症因子及呼吸指标的变化和术后并发症的发生情况。结果：在T1、T2、T3时间点，呼气末二氧化碳分压（PETCO2）指标B组和C组均低于A组（P<0.05），C组均显著低于B组（P<0.01）；气道峰压指标C组均显著高于A组和B组（P<0.01）。A组和B组病人在T1、T2、T3时间点的PETCO2组内比较差异均无统计学意义（P>0.05）；C组病人在T1、T2、T3时间点的PETCO2差异均有统计学意义（P<0.01），T2、T3时间点均显著低于T1时间点（P<0.01）；3组病人在T1、T2、T3时间点的气道峰压指标组内比较差异均有统计学意义（P<0.01），A组和B 组T3时间点均高于T1、T2时间点（P<0.01），C组T2、T3时间点均显著高于T1时间点（P<0.01）。白细胞介素-1β在T2时间点3组差异均有统计学意义（P<0.01），B组和C组均低于A组（P<0.05）；白细胞介素-6在T2、T3时间点3组差异均有统计学意义（P<0.01），T2、T3时间点B组低于A组（P<0.05），T3时间点C组高于A组（P<0.05）；肺顺应性指标在T1、T2、T3时间点3组差异均有统计学意义（P<0.01），B组和C组均显著低于A组（P<0.01），在T2、T3时间点C组均显著高于B组（P<0.01）。3组总体并发症发生情况的差异具有统计学意义（P<0.05），且B组总体并发症发生率明显降低（P<0.05）。结论：术中选择8 mL/kg潮气量机械通气对老年肺癌病人术后血气指标、炎症因子影响小，不影响病人肺换气功能，且并发症发生率低，是较为合理的机械通气潮气量。

       

      Abstract: Objective:To explore the effects of the different tidal volume of mechanical ventilation on postoperative old patients with lung cancer.Methods:One hundred postoperative elderly patients with lung cancer were divided into the 6 mL/kg group(group A),8 mL/kg group(group B) and 10 mL/kg(group C) according to the tidal volume of mechanical ventilation.The postoperative blood gas analysis indicators,related inflammatory factors,respiratory indexes and complications between three groups were compared.Results:At timepoint T1,T2 and T3,the levels of PETCO2 in group B and C were lower than that in group A(P<0.05),which in group C was significantly lower than that in group B(P<0.01).The peak airway pressure level in group C was significantly higher than that in group A and B(P<0.01).The differences of the levels of PETCO2 between timepoint T1,T2 and T3 in group A and B were not statistically significant(P>0.05).The differences of the levels of PETCO2 between timepoint T1,T2 and T3 in group C were statistically significant(P<0.01),and which at T2 and T3 was significantly lower than that at timepoint T1(P<0.01).The differences of the levels of peak airway pressure between three groups at timepoint T1,T2 and T3 were statistically significant(P<0.01),which at timepoint T3 in group A and B were higher than that at timepoint T1 and T2(P<0.01),and which at timepoint T2 and T3 in group C were significantly higher than that at timepoint T1(P<0.01).There were statistical significances in the level of IL-1β between three groups at timepoint T2(P<0.01),which in group B and C was lower than that in group A(P<0.05).There were statistical significances in the level of IL-6 between three groups at timepoint T2 and T3(P<0.01),which in group B at timepoint T2 and T3 were lower than that in group A(P<0.05),and which in group C at timepoint T3 was higher than that in group A(P<0.05).There were statistical significances in lung compliance indicators between three groups at timepoint T1,T2 and T3(P<0.01),which in group B and C were lower than that in group A(P<0.01),and which in group C at timepoint T2 and T3 were significantly higher than that in group B(P<0.01).There were statistical significances in overall complications between three groups(P<0.05),and which in group B significantly decreased(P<0.05).Conclusions:The effects of 8 mL/kg tidal volume of mechanical ventilation on the postoperative blood gas index,inflammatory factors and complications in elderly patients with lung cancer is little,which does not affect the lung ventilation function,and is a reasonable tidal volume of mechanical ventilation.

       

      • HTML全文
      • 参考文献(14)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回