Abstract: Objective:To investigate the expression levels of SRY-related HMG-box 4(Sox4) and epithelial-mesenchymal transition related protein E-cadherin in cervical squamous cell carcinoma(CSCC),and their clinical significance.Methods:The expression levels of Sox4 and E-cadherin proteins in CSCC group(160 cases) and control group(28 cases) were detected by S-P immunohistochemical method,and the relationships between which and clinicopathological parameters were analyzed.Results:The positive rate of Sox4 in observation group(63.75%) was higher than that in control group(39.29%)(P<0.05).The positive rate of E-cadherin in observation group(35%) was lower than that in control group(64.29%)(P<0.05).The expression level of Sox4 was negatively correlated with E-cadherin(P<0.01),closely related to the tumor diameter,lymph node metastasis,parametrial infiltration and FIGO stage(P<0.05 to P<0.01),and unrelated to the age of patients(P>0.05).Conclusions:Sox4 may promote the occurrence,development,invasion and metastasis of CSCC by down-regulating the E-cadherin protein.The combined detection of Sox4 and E-cadherin can provide the reference in early diagnosis,treatment and predicting the prognosis of patients with CSCC.