Abstract: Objective: To study the application effects of case-based learning(CBL) combined with standardized patients(SP) teaching model in the standardized training of gynecology and obstetrics residents.Methods: Sixty newly enrolled gynecology and obstetrics trainees were randomly divided into the two groups.The two groups were trained with SP combined with CBL and lecture-based learning(LBL) model,respectively.After 2 years of clinical training,the clinical comprehensive abilities in two groups were evaluated.The satisfaction of two teaching methods of trainees was investigated using questionnaire.Results: Compared with the LBL teaching model,the SP combined with CBL teaching model could significantly improve the clinical thinking ability,ability of communicating with patients and learning interest of trainees(P<0.01).Conclusions: The SP combined with CBL teaching model is practicable in the standardized training of obstetrics and gynecology residents,and has good teaching effect.