Abstract: Objective: To explore the application effects of continuous quality improvement(CQI) in the prevention of complications caused by artificial liver therapy.Methods: The clinical data of 24 patients treated with artificial liver from October 2015 to December 2016 were retrospectively analyzed(control group),and the major complication of the patients was summarized.Twenty-four patients patients treated with artificial liver from April to December 2017 were randomly selected,and set as the observation group.The corresponding countermeasures to the related factors of complication in control group were formulated,and the CQI measurement was implemented in observation group.The incidence rates of infection,bleeding and hematoma,deep vein thrombosis and allergic reaction between two groups were compared.Results: The incidence rates of infection,allergic reaction and bleeding and hematoma in observation group,were lower than those in control group,respectively(P<0.05 to P<0.01).The difference of the incidence rate of deep vein thrombosis between the two groups was not statistically significant(P>0.05).Conclusions: Continuous quality improvement can reduce the incidence rate of complications caused by artificial liver therapy,and improve the therapeutic effects.