多囊卵巢综合征血抗苗勒管激素与临床内分泌指标相关性分析

于艳丽; 葛秋迎; 于秀娟; 王金梅

doi:10.13898/j.cnki.issn.1000-2200.2018.06.010

多囊卵巢综合征血抗苗勒管激素与临床内分泌指标相关性分析

Correlation study of the serum level of AMH with clinical endocrine indicators in patients with PCOS

摘要

摘要: 目的：探讨多囊卵巢综合征（PCOS）不孕病人血抗苗勒管激素（AMH）水平与性激素及内分泌代谢指标之间的相关性。方法：选取PCOS不孕病人71例作为观察组，同期健康体检女性50名作为对照组，分析2组的体质量指数、AMH、卵泡刺激素、黄体生成素、睾酮（T）、雌二醇、空腹胰岛素、空腹血糖、总胆固醇、三酰甘油、低密度脂蛋白、稳态模型胰岛素抵抗指数、双侧卵巢2~9mm窦卵泡数之间的相关性。结果：观察组体质量指数、AMH、黄体生成素、T、空腹胰岛素、稳态模型胰岛素抵抗指数及2~9mm窦卵泡数均高于对照组（P<0.01）；Pearson相关分析显示，观察组血AMH与T和多囊卵巢（PCO）呈正相关关系（P<0.01），与其他变量无明显相关关系（P>0.05）；多重线性回归分析显示，T和PCO影响血AMH水平（P<0.01）。结论：T和PCO是AMH水平的影响因素。

Abstract: Objective:To explore the correlations of the serum level of anti-Mullerian hormone(AMH) and sex hormone with endocrine and metabolism indicators in patients with infertility polycystic ovary syndrome(PCOS).Methods:Seventy-one patients with infertility PCOS and 50 normal physical examination women were divided into the observation group and control group,respectively.The correlations of the levels of BMI,serum AMH,FSH,LH,T,E2,FINS,GLU,CHOL,TG,LDL,HOMA-IR and number of 2-9mm follicles in both ovaries in two groups were analyzed.Results:The levels of BMI,serum AMH,LH,T,GLU,FINS,HOMR-IR and number of 2-9mm follicles in observation group were higher than those in control group(P<0.01).Pearson correlation analysis showed that the AMH level was positively correlated with T and PCO(P<0.01),and without other variables(P>0.05).The multiple linear analysis showed that T and PCO influenced the serum AMH level(P<0.01).Conclusions:The T and PCO are the influencing factors of serum AMH level.

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