Abstract: Objective:To investigate the effects of intensive glucose lowering combined with rosiglitazone on the levels of blood lipid and apolipoprotein in senile coronary heart disease(CHD) patients complicated with type 2 diabetes.Methods:Seventy-two senile CHD patients complicated with type 2 diabetes were randomly divided into the control group and observation group(36 cases each group).The control group and observation group were treated with intensive glucose lowering and intensive glucose lowering combined with rosiglitazone for 3 months,respectively.Two groups were followed up for 12 months.The clinical curative effect between two groups was compared,the blood lipid and apolipoprotein levels before and after treatment in two groups were detected,and the cardiovascular adverse events in two groups were observed during the following-up period.Results:After the treatment,the total effective rate in observation group(88.89%) was higher than that in control group(69.44%)(P<0.05),the levels of total cholesterol(TC),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C) and apolipoprotein B(Apo B) in two groups decreased(P<0.05 to P<0.01),the levels of high density lipoprotein cholesterol(HDL-C) and apolipoprotein A1(Apo A1) in two groups increased(P<0.05 to P<0.01),and the decreasing degrees of the levels of TC,TG,LDL-C and Apo B,and increasing degrees of the levels of HDL-C and Apo A1 in observation group were higher than those in control group(P<0.05 to P<0.01).During the following-up,the incidence rate of adverse event in observation group(22.22%) was lower than that in control group(44.44%)(P<0.05).Conclusions:The intensive glucose lowering combined with rosiglitazone in the treatment of the senile CHD patients complicated with type 2 diabetes can significantly improve the levels of blood lipid and apolipoprotein,decrease the adverse event,and the effect of which is significant.