Abstract: Objective: To investigate application value of cryotherapy in the personalized treatment of cervical lesions.Methods: The high-risk HPV infection and low cervical precancerous lesions patients were investigated.The patients were treated with cervical cryotherapy,loop electrosurgical excision procedure(LEEP) and cervical laser surgery according to the age(25 to 30 years old) and fertility requirements(40 cases each group).The operation time,intraoperative blood loss,postoperative 3 months colposcopy,cervical contracture,length change of cervical canal between before and after treatment,postoperative 6 months negative conversion rate of HPV,postoperative 2 years fertility condition(including vaginal delivery and miscarriage) in three groups were observed.Results: The difference of operation time between LEEP and cervical laser surgery was not statistically significant(P>0.05),and which was shorter than that in cervical cryotherapy(P<0.01).No bleeding was found in cryosurgery operation,the intraoperative blood loss in LEEP was higher than that in laser surgery(P<0.01).During the 3 months of following-up,the differences of abnormal pathology rates among three groups were not statistically significant(P>0.05).The cervical contracture rate in cryotherapy was lower than that in LEEP surgery,and the difference of cervical contracture rate between laser surgery and LEEP was not statistically significant(P>0.05).No postoperative change of cervical tube length was found in cryotherapy surgery,and the cervical tube length change in LEEP surgery was more than that in laser surgery(P<0.01).The differences of the negative conversion rate of HPV at postoperative 6 months,and pregnant rate at postoperative 2 months among three groups were not statistically significant(P>0.05).The vaginal delivery rate in patients treated with cryotherapy(74.07%) was higher than that in the patients treated with LEEP(41.67%) and cervical cryotherapy(48.00%)(P<0.05),and the difference of which between LEEP and laser surgery patients was not statistically significant(P >0.05).The abortion rates in LEEP,laser surgery and cryotherapy pateints were 20.83%,8.00% and 0.00%,respectively,and which in patients treated with cryotherapy was lower than that in patients treated with LEEP(P<0.05).Conclusions: The cervical cryotherapy treatment does not have scar,change the cervical tube length,adhesion and contracture,and affect fertility function,which is suitable for young childless or retaining fertility requirements patients.