Abstract: Objective: To explore the effects of the targeted infusion of propofol and remifentanil on the anesthesia effect and postoperative cognitive function in patients treated with laparoscopic cholecystectomy.Methods: The patients treated with laparoscopic cholecystectomy was divided into the control group and observation group.The control group was intravenously injected with propofol and fentanyl,and the observation group was treated with target infusion of propofol and remifentanil.Results: The differences of the systolic pressure,diastolic pressure and heart rate between two groups before and after intubation were not statistically significant(P>0.05),and the diastolic pressure and heart rate in two groups after intubation were higher than those before intubation(P<0.05 to P<0.01).The differences of the postoperative recovery time of spontaneous breathing,eye opening time,anesthesia time and extubation time between two groups were not statistically significant(P>0.05),and the recovery time of orientation in observation group was significantly shorter than that in control group(P<0.01).Compared with the extubation,after 24 h extubation,the OAAS score of the control group increased significantly and the NRS score decreased significantly(P<0.01),The score of OAAS and MMSE in the observation group increased significantly(P<0.01) and the NRS score decreased significantly(P<0.05),and the MMSE score of the 24 h observation group was significantly higher than that of the control group(P<0.05).The difference of the incidence rate of postoperative complications between two groups was not statistically significant(P>0.05).Conclusions: The targeted infusion of propofol and remifentanil in patients treated with laparoscopic cholecystectomy can sustain hemodynamics and improve the quality of sleep,which has good effect and is worthy of application and promotion.