Abstract: Objective:To investigate the effects of alprostadil on the renal function and inflammatory factors in patients with hepatorenal syndrome.Methods:A total of 76 patients with hepatorenal syndrome was randomly divided into the observation group and control group.The control group was treated with routine measure,and the observation group were treated with alprostadil on the basis of control group.The improvement of renal function and inflammatory factors between two groups were compared.Results:Before treatment,the difference of the related index between two groups was not statistically significant(P>0.05).After 2 weeks of treatment,the levels of serum total bilirubin,alanine aminotransferase,cystatin C and C-reactive protein in the observation group were lower than those in control group(P<0.01),and the levels of albumin and 24-hour urine volume in observation group were significantly higher than those in control group(P<0.01).Conclusions:The effect of alprostadil in treating the hepatorenal syndrome is reliable,which can effectively protect the renal function,significantly improve the inflammatory status,and is worthy of promotion in clinic.