Abstract: Objective:To investigate the risk factors of contrast-induced nephropathy(CIN) in acute myocardial infarction(AMI) patients treated with emergence percutaneous coronary intervention(PCI).Methods:One hundred and ten AMI patients treated with emergency PCI were divided into the CIN group and non-CIN group.The drug dosage,basic disease,preoperative medication and general data between two groups were compared,and the related risk factors of CIN were analyzed.Results:The differences of the renal replacement therapy,stroke,blood transfusion,angina and death between two groups were not statistically significant(P>0.05).During hospitalization,the mechanical ventilation,acute heart failure,aortic balloon pacing assistance,and arrhythmias in CIN group were higher than those in non-CIN group(P<0.05 to P<0.01).The blood glucose,hypersensitive C-reactive protein(hs-CRP),creatinine kinase peak value,anemia,serum creatinine(Scr) and contrast dose (CMV) in CIN group were significantly higher than those in non-CIN group(P<0.05 to P<0.01).The glomerular filtration rate(eGFR),hemoglobin,left ventricular ejection fraction (LVEF) in CIN group were lower than those in non-CIN group(P<0.05 to P<0.01).Multivariate analysis results showed that the CMV,renal insufficiency,Scr,LVEF,eGRF,diabetes,anemia,hs-CRP and ratio of CMV/eGFR were the risk factors of the occurrence of CIN(P<0.05 to P<0.01).Conclusions:The CMV,renal insufficiency,Scr,LVEF,eGRF,diabetes,anemia,hs-CRP and ratio of CMV/eGFR in AMI patients treated with emergence PCI should be strictly controlled to decrease the occurrence of CIN.