Abstract: Objective:To compare the clinical application value between four-dimensional and two-dimensional color Doppler ultrasound in the diagnosis of fetal abnormality.Methods:Sixty-eight pregnant women with fetal malformation were examined using four-dimensional and two-dimensional color Doppler ultrasound,and the fetal malformation was observed.Results:Fifty-two malformation fetuses were detected using the two-dimensional ultrasound,and the positive detection rate of which was 76.47%.Sixty-seven malformation fetuses were detected using the four-dimensional ultrasound,the positive detection rate of which was 98.53%,which was higher than that of two-dimensional ultrasound(P<0.05).The accuracy rates of four-dimensional color Doppler ultrasound in the diagnosis of face,heart,face,limbs and trunk deformity were 100%,93.75%,100.00 and 100.00%,respectively,which was higher than that of two-dimensional ultrasound(P<0.05 to P<0.01).Conclusions:The accuracy rate of four-dimensional color Doppler ultrasound in the diagnosis of fetal malformation is higher than that of two-dimensional ultrasound,and the four-dimensional image can easily be recognized.