糖化血红蛋白与冠心病病人心肌外脂肪厚度的相关性研究

范益博; 幺天保; 袁安彩; 邵琴; 卜军

doi:10.13898/j.cnki.issn.1000-2200.2018.10.024

糖化血红蛋白与冠心病病人心肌外脂肪厚度的相关性研究

Study on the correlation between glycosylated hemoglobin and epicardial adipose tissue thickness in CHD patients

摘要

摘要: 目的：探讨糖化血红蛋白水平与冠心病病人心肌外脂肪厚度（epicardial adipose tissue thickness，EATT）的关系。方法：选择入院诊断为冠心病的住院病人共510例，均行冠脉造影检查，并根据造影结果将入选者分为冠心病组和对照组。对所有入选者进行心脏多层螺旋CT扫描，根据CT图像分别测定前降支、回旋支和右冠脉区域的EATT，并计算三者的厚度之和（Total EATT），同时测定血清糖化血红蛋白等指标。结果：冠心病组平均糖化血红蛋白为（6.2±1.2）mmol/L，高于对照组的（5.8±0.8）mmol/L（P<0.01），冠心病组Total EATT（26.33±7.8）mm，高于对照组的（22.72±6.3）mm（P<0.01）。在冠心病病人中，糖化血红蛋白水平与Total EATT呈正相关关系（r=0.207，P<0.01）；多元回归分析表明，糖化血红蛋白与Total EATT呈独立正相关关系（P<0.01）。结论：冠心病病人中，EATT增加可能与糖化血红蛋白水平增高有关。

Abstract: Objective:To explore the relationship between glycosylated hemoglobin level and epicardial adipose tissue thickness(EATT) in coronary heart disease(CHD) patients.Methods:A total of 510 patients with CHD were examined using coronary arteriography,and divided into the CHD group and control group according to the results of coronary arteriography.The EATT in anterior descending branch,cyclotron branch and right coronary artery were measured according to multilayer spiral cardiac CT scan imaging,the total thickness of the three(Total EATT) was calculated,and the lycosylated hemoglobin were measured.Results:The mean glycosylated hemoglobin level in CHD group(6.2±1.2)mmol/L was significantly higher than that in control group(5.8±0.8)mmol/L)(P<0.001).The Total EATT in CHD group(26.33±7.8)mm was significantly higher than that in control group(22.72±6.3)mm)(P<0.01).The glycosylated hemoglobin level was positively correlated with the Total EATT(r=0.207,P<0.01).Multivariate regression analysis showed that the glycosylated hemoglobin level was an independent predictor of Total EATT(P<0.01).Conclusions:The glycosylated hemoglobin level increasing is positively correlated with EATT in CHD patients.

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