Abstract: Objective: To research the efficacy and advantage of laparoscopic pyloromyotomy(LP) and open right upper quadrant small incision pyloromyotomy(OP) for the treatment of congenital hypertrophic pyloric stenosis.Methods: Eighty-five patients with congenital hypertrophic pyloric stenosis were divided into LP group(35 cases) and OP group(50 cases). The perioperative,postoperative,and related complications between two groups were compared.Results: The operation time,blood loss during operation and hospitalization time in LP group were obviously lower than those in OP group(P<0.01). The difference of delayed wound healing in two groups was not statistically significant(P>0.05).Conclusions: LP is safe,effective and feasible for hypertrophic pyloric stenosis with mini-invasion,little injury,little blood loss,quick recovery,short operation time and hospitalization time,which is worthy of clinical promotion.