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    王红蕾, 赵卫东. 低分子肝素联合间歇性充气压力系统预防腹腔镜下宫颈癌根治术后下肢深静脉血栓的作用[J]. 蚌埠医科大学学报, 2018, 43(11): 1440-1443. DOI: 10.13898/j.cnki.issn.1000-2200.2018.11.013
    引用本文: 王红蕾, 赵卫东. 低分子肝素联合间歇性充气压力系统预防腹腔镜下宫颈癌根治术后下肢深静脉血栓的作用[J]. 蚌埠医科大学学报, 2018, 43(11): 1440-1443. DOI: 10.13898/j.cnki.issn.1000-2200.2018.11.013
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    WANG Hong-lei, ZHAO Wei-dong. Effect of low molecular heparin combined with intermittent pneumatic pressure system in the prevention of deep venous thrombosis of lower extremities after laparoscopic radical cervical cancer surgery[J]. Journal of Bengbu Medical University, 2018, 43(11): 1440-1443. DOI: 10.13898/j.cnki.issn.1000-2200.2018.11.013
    Citation: WANG Hong-lei, ZHAO Wei-dong. Effect of low molecular heparin combined with intermittent pneumatic pressure system in the prevention of deep venous thrombosis of lower extremities after laparoscopic radical cervical cancer surgery[J]. Journal of Bengbu Medical University, 2018, 43(11): 1440-1443. DOI: 10.13898/j.cnki.issn.1000-2200.2018.11.013
    shu

    低分子肝素联合间歇性充气压力系统预防腹腔镜下宫颈癌根治术后下肢深静脉血栓的作用

    Effect of low molecular heparin combined with intermittent pneumatic pressure system in the prevention of deep venous thrombosis of lower extremities after laparoscopic radical cervical cancer surgery

      摘要
    • 摘要: 目的：探讨腹腔镜下宫颈癌根治术后应用低分子肝素联合间歇性充气压力系统（IPC）预防下肢静脉血栓（DVT）的临床意义。方法：选取129例宫颈癌ⅠB1～ⅡA1期病人，随机分为对照组63例和观察组66例。观察组于术后6 h使用IPC，术后24 h注射低分子肝素；对照组给予一般性预防措施。比较2组手术时间、术中出血量、术后高危因素和卧床时间，并分别检测2组病人手术前后血小板（PLT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）、D-二聚体（D-D）和纤维蛋白原（FIB）水平等指标，并常规行双下肢静脉彩超检查。结果：2组病人手术时间、术中出血量和卧床时间差异均无统计学意义（P>0.05），术中输血及术后高危因素人数差异亦均无统计学意义（P>0.05）。2组病人术前PLT、PT、APTT和FIB、D-D差异均无统计学意义（P>0.05）；术后第1~7天，2组病人PLT差异均无统计学意义（P>0.05），观察组FIB、D-D水平均明显低于对照组（P<0.01）；术后第1~5天，观察组PT和APTT均低于对照组（P<0.05~P<0.01）。观察组下肢DVT总发生率为1.52%（1/66），低于对照组的11.11%（7/63）（P<0.05）。结论：低分子肝素联合IPC可降低腹腔镜下宫颈癌根治术后下肢DVT发生率。

       

      Abstract: Objective: To investigate the clinical significance of low molecular weight heparin(LMWH) combined with intermittent pneumatic pressure system(IPC) in the prevention of deep venous thrombosis(DVT) of lower extremities after laparoscopic radical cervical cancer surgery.Methods: One hundred and twenty-nine cervical cancer(FIGO ⅠB1-ⅡA1) patients were randomly divided into the control group(63 cases) and observation group(66 cases.The observation group were treated with IPC after 6h of operation,and LMWH after 24 h of operation.The control group were treated with general precautions.The operation time,peroperative bleeding,postoperative risk factors,and duration for bed rest between two groups were compared.Before and after operation,the levels of PLT,PT,APTT,D-D and FIB in two groups were measured,and the lower limbs vein were examined using ultrasound.Results: There was no statistical significance in operation time,blood loss,duration for bed rest,intraoperative blood transfusion and number of people with postoperative risk factors between two groups(P>0.05).The differences of the levels of PLT,PT,APTT,FIB and D-D between two groups before operation were not statistical significance(P>0.05).After 1 to 7 days of operation,the difference of the level of PLT between two groups was not statistical significance(P>0.05),and the levels of FIB and D-D in observation group were significantly lower than those in control group(P<0.01).After 1 to 5 days of operation,the levels of PT ad APTT in observation group were lower than those in control group(P<0.05 to P<0.01).The total incidence of thrombosis in observation group(1.52%) was lower than that in control group(11.11%)(P<0.05).Conclusions: LWMH combined with IPC can significantly prevent the incidence of DVT after laparoscopic radical cervical cancer.

       

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