Abstract: Objective: To investigate the clinical effects of D2 gastric cancer radical operation assisted by laparoscopy,and its effect on abdominal micrometastasis.Methods: Ninety-two early gastric cancer patients were randomly divided into the laparoscopy group and laparotomy group(46 cases each group).The laparoscopy group and laparotomy group were treated with gastric cancer radical operation assisted by laparoscopy and laparotomy,respectively.The clinical indicators and abdominal micrometastases index before and after operation between two groups were compared.Results: The operation time in laparoscopy group was significantly longer than that in laparotomy group(P<0.01),the incision length,intraoperative blood loss,out of bed activity time,intestinal function recovery time and hospital stay in laparoscopy group were less than those in laparotomy group(P<0.05 to P<0.01),and the difference of the number of intraoperative cleaning lymph node between two groups was not statistically significant(P>0.05).The differences of the levels of dopamine decarboxylase(DDC) and carcinoembryonic antigen(CEA) between two groups before operation were not statistically significant(P>0.05).After operation,the levels of DDC and CEA in two groups were significantly higher than those of before operation(P<0.01),and the levels of DDC and CEA in laparoscopy group were lower than those in laparotomy group(P<0.01).Conclusions: The curative effect of D2 gastric cancer radical operation assisted by laparoscopy is good,which is minimally invasive and has low postoperative abdominal micrometastasis.