Abstract: Objective: To investigate the AIDS-related knowledge,attitude,behavior and interventions among normal university and medical college freshmen,and provide the scientific evidence for preventing and treating AIDS among this two kinds of university.Methods: One thousand three hundred and sixty-four freshmen from normal university and medical college freshmen were investigated using self-compiled questionnaire.Results: In terms of HIV awareness,the correct rate of 8 AIDS knowledge problems in medical college freshmen(6 items correct) was higher than that in normal university freshmen(P<0.01),and the difference of the correct rate of two problems between two schools was not statistically significant(P>0.05).The discrimination rate of normal university freshmen to family member with AIDS(48.32%) was higher than that in medical college freshmen(31.42%)(P<0.01).The difference of the incidence rate of sexual behavior between medical college freshmen(4.55%) and normal university freshmen(4.84%) was not statistically significant(P>0.05).The unsafe sexual behavior was found in freshmen.The AIDS-related prevention knowledge was advertised in 46.85% normal university freshmen and 40.09% medical college freshmen at recent year.Conclusions: Basing on different mastery of AIDS knowledge between normal university and medical college,the systematic and professional AIDS health education activities should be pertinently carried out to promote the healthy development of students and long-term development of AIDS prevention and treatment.