Abstract: Objective: To investigate the changes of serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ,and its ratio in patients with primary hypertension.Methods: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ of fasting venous blood in 107 patients with primary hypertension were detected using enzyme-linked immunosorbent assay,and the difference of which between two groups was compared.Results: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ in patients with primary hypertension were significantly higher than those in control group(P<0.01).The difference of the ratio of pepsinogen Ⅰ and pepsinogen Ⅱ between two groups was not statistically significant(P<0.05).Conclusions: The serum levels of pepsinogen Ⅰ and pepsinogen Ⅱ in patients with primary hypertension significantly increase,which may be related to the primary hypertension under excluding stomach diseases.