Abstract: Objective: To investigate the effects of oral cavity nursing intervention based on the dietary guidance on the compliance behavior in patients with dental ulcer.Methods: One hundred patients with dental ulcer were divided into the observation group and control group according to the random number table method(50 cases each group).The control group was intervened using conventional oral nursing,and the observation group was intervened using oral cavity nursing intervention based on the dietary guidance on the basis of control group.The compliance behavior in two groups was evaluated using the modified Morisky adherence questionnaire(MMAS-8),the pain degree in two groups was assessed using the visual analogue scale(VAS),the knowledge of dental ulcer and diet in two groups was evaluated using the self-made questionnaire,and the risk factors of influencing the ulcer healing in two groups were analyzed.Results: The mastery rates of the disease and diet knowledge in observation group were significantly higher than that in control group(P<0.01).After 1,4 and 7 d of intervention,the VAS scores and MMAS-8 scores in observation group were significantly lower and higher than those in control group,respectively(P<0.01).After intervention,the feeding compliance rate of all kinds of food in observation group was higher than that in control group(P<0.05 to P<0.01),the excellent rate of mouth healing in observation group was higher than that in control group(P<0.05),and the healing time in observation group was significantly shorter than that in control group(P<0.01).Logistic regression analysis results showed that the unknowledge of disease and diet,degree of pain,poor compliance behavior and underfeeding were the independent risk factors of the poor healing(P<0.01).Conclusions: The oral cavity nursing intervention based on the dietary guidance can effectively improve the compliance behavior and healing effect,and alleviate the pain of patients,which is worthy of promotion in clinic.