Abstract: Objective:To investigate the clinical effects of artificial liver plasma replacement in the treatment of liver failure in 40 patients,and evaluate the value of model for end-stage liver disease(MELD) score in predicting the prognosis of liver failure.Methods:The clinical data of 40 liver failure patients treated with artificial liver plasma replacement were retrospectively analyzed.The clinical effects and MELD scores of the patients were evaluated,and the clinical outcome of the patients was observed.Results:After the plasma replacement,the levels of ALT,AST,TBIL,Cr,PT and INR significantly decreased(P<0.05 to P<0.01),and the levels of CHE,ALB and PTA significantly increased compared with before treatment(P<0.01).The patients were treated with artificial liver plasma replacement for 140 times,the adverse reactions occurred in 4 times,and the incidence rate of which was 2.8%.Thirty cases were effective,10 cases were invalid,and the effective rate of which was 75%.The invalid rate of artificial liver treatment in three groups with high MELD scores was higher,and the difference of invalid rate was not statistically significant(P>0.05).Conclusions:The plasma replacement has good clinical effects and few adverse reactions.MELD sore as a predicting prognosis indictor of plasma replacement treating liver failure needs further research.