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    131Ⅰ治疗分化型甲状腺癌肺转移的疗效及影响因素分析

    Analysis of the efficacy and influencing factors of 131Ⅰ in the treatment of lung metastasis of differentiated thyroid carcinoma

      摘要
    • 摘要:
      目的分析131Ⅰ治疗分化型甲状腺癌(DTC)肺转移的疗效及影响因素。
      方法回顾性分析124例确诊为DTC肺转移的病人给予相应剂量的131Ⅰ治疗，对年龄、性别、病理类型、局部淋巴结转移、肺外远处转移、清灶治疗前血甲状腺球蛋白(Tg)水平、手术方式、术后治疗时间和肺部摄取131Ⅰ形态等9个因素进行分析，评价131Ⅰ治疗疗效及影响因素。
      结果病人的年龄、清灶治疗前血Tg水平及肺外远处转移与疗效有关(P < 0.05~P < 0.01)；经多因素分析，肺外远处转移是影响131Ⅰ治疗疗效的重要影响因素(P < 0.05)。
      结论131Ⅰ治疗DTC肺转移疗效较好，肺外远处转移是影响DTC肺转移疗效的确切因素。

       

      Abstract:
      ObjectiveTo analyze the efficacy and influencing factor of 131Ⅰ in the treatment of lung metastasis of differentiated thyroid carcinoma(DTC).
      MethodsThe clinical data of 124 DTC patients with lung metastasis treated with 131Ⅰ were retrospectively analyzed.The age, gender, pathological type, local lymph node metastasis, distant metastasis of lung, serum Tg level before treatment with clearance of residual thyroid gland, operation method, postoperative treatment time and 131Ⅰ form of lung uptaking in all patients were analyzed, and the therapeutic efficacy and influencing factor of 131Ⅰ were evaluated.
      ResultsThe age, serum Tg level before treatment with clearance of residual thyroid gland and distant metastasis of lung were related to the curative effects(P < 0.05 to P < 0.01).The Results of multivariate analysis showed that the distant metastasis of lung was the important factor in influencing the therapeutic effect of 131Ⅰ(P < 0.05).
      ConclusionsThe effect of 131Ⅰ in the treatmet of the lung metastasis of DTC is good, and the distant metastasis of lung is the exact factor influencing the curative effect.

       

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