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    宋红涛, 王立金, 沐林林, 许华山, 谢杏利, 翟长平, 张俊, 吴延海, 崔明. 精神分裂症病人外周血差异表达miRNA-181b的生物信息学分析[J]. 蚌埠医科大学学报, 2019, 44(2): 173-177. DOI: 10.13898/j.cnki.issn.1000-2200.2019.02.010
    引用本文: 宋红涛, 王立金, 沐林林, 许华山, 谢杏利, 翟长平, 张俊, 吴延海, 崔明. 精神分裂症病人外周血差异表达miRNA-181b的生物信息学分析[J]. 蚌埠医科大学学报, 2019, 44(2): 173-177. DOI: 10.13898/j.cnki.issn.1000-2200.2019.02.010
    shu
    SONG Hong-tao, WANG Li-jin, MU Lin-lin, XU Hua-shan, XIE Xing-li, ZHAI Chang-ping, ZHANG Jun, WU Yan-hai, CUI Ming. Bioinformatics analysis of the differential expression of miRNA-181b in peripheral blood of schizophrenic patients[J]. Journal of Bengbu Medical University, 2019, 44(2): 173-177. DOI: 10.13898/j.cnki.issn.1000-2200.2019.02.010
    Citation: SONG Hong-tao, WANG Li-jin, MU Lin-lin, XU Hua-shan, XIE Xing-li, ZHAI Chang-ping, ZHANG Jun, WU Yan-hai, CUI Ming. Bioinformatics analysis of the differential expression of miRNA-181b in peripheral blood of schizophrenic patients[J]. Journal of Bengbu Medical University, 2019, 44(2): 173-177. DOI: 10.13898/j.cnki.issn.1000-2200.2019.02.010
    shu

    精神分裂症病人外周血差异表达miRNA-181b的生物信息学分析

    Bioinformatics analysis of the differential expression of miRNA-181b in peripheral blood of schizophrenic patients

      摘要
    • 摘要:
      目的对精神分裂症病人外周血中差异表达的miRNA-181b进行靶基因、转录因子和信号通路的分析。
      方法采用DIANA-TarBase数据库分析miRNA-181b靶基因，应用DIANA-miPath V.3软件对miRNA-181b的靶基因进行GO功能富集分析和KEGG信号通路富集分析，运用DIANA-miRGen v3.0数据库分析miRNA-181b的转录因子。
      结果miRNA-181b靶基因共1 344个，其中显著表达的共有靶基因是ARHGAP11A、PPA1、YY1和ZC3H12B；miRNA-181b的靶基因广泛参与生物学过程的调节，包括分子功能、RNA结合、细胞组成等过程；KEGG生物信息学分析发现miRNA-181b的靶基因富集了12条信号通路，包括hippo信号通路、p53信号通路、HIF-1信号通路、赖氨酸的降解等；与miRNA-181b显著关联的转录因子有7个，其中JUN、EGR1、MEF2C与精神分裂症有显著关联。
      结论对精神分裂症病人外周血中差异表达的miRNA-181b进行生物信息学分析，发现了多个靶基因、信号通路和转录因子与精神分裂症的发病有密切关联。

       

      Abstract:
      ObjectiveTo analyze the target gene, transcription factor and signal pathway of the differential expression of miRNA-181b in the peripheral blood of schizophrenic patients.
      MethodsThe miRNA-181b target gene was analyzed using the DIANA-TarBase database, the GO function and KEGG pathway enrichment of miRNA-181b gene were analyzed using DIANA-miPath V.3 software, and the transcription factors of miRNA-181b were analyzed using the DIANA-miRGen v3.0 database.
      ResultsThere were 1 344 target genes of miRNA-181b, and the target genes ARHGAP11A, PPA1, YY1 and ZC3H12B significantly expressed.The target genes of miRNA-181b were widely involved in the regulation of biological processes(including molecular function, RNA binding and cell composition).The results of KEGG bioinformatics analysis showed that the target gene of miRNA-181b enriched 12 signal pathways, which included the hippo signal pathway, p53 signal pathway, HIF-1 signal pathway and lysine degradation.Seven transcription factors were significantly associated with miRNA-181b, and JUN, EGR1 and MEF2C were significantly associated with schizophrenia.
      ConclusionsThe multiple target genes, signal pathways and transcription factors are closely related to the onset of schizophrenia using the bioinformatics analysis of the differential expression of miRNA-181b in the peripheral blood of schizophrenic patients.

       

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