胱抑素C与高血压性脑出血及其颈动脉粥样硬化斑块的相关性研究

张如梦; 薛东章; 王轶群; 杨世泉; 程晋成; 李雪萍

doi:10.13898/j.cnki.issn.1000-2200.2019.02.017

胱抑素C与高血压性脑出血及其颈动脉粥样硬化斑块的相关性研究

Study on the correlation between cystatin C, and hypertensive intracerebral hemorrhage and carotid atherosclerotic plaque

摘要

摘要:
目的探讨胱抑素C（Cys C）与高血压性脑出血及其颈动脉粥样硬化斑块的相关性。
方法选取115例高血压性脑出血病人作为观察组和71名健康体检者作为对照组，对2组一般资料及实验室检查等临床资料进行比较，并对脑出血危险因素进行多因素logistic回归分析；同时对脑出血病人进行颈动脉彩色超声检查，根据有无动脉粥样硬化斑块分为斑块组（57例）和无斑块组（58例），对2组一般资料及实验室检查等临床资料进行比较，并对斑块形成的危险因素进行多因素logistic回归分析。
结果观察组Cys C、C反应蛋白明显高于对照组（P < 0.01），高密度脂蛋白水平明显低于对照组（P < 0.01）；多因素logistic回归分析显示，Cys C、C反应蛋白水平是脑出血的独立危险因素。斑块组年龄、高血脂病史比例、Cys C水平高于无斑块组（P < 0.05~P < 0.01）；多因素logistic回归分析显示，年龄、Cys C水平是脑出血病人颈动脉斑块形成的独立危险因素。
结论血清Cys C水平与高血压性脑出血及颈动脉斑块形成密切相关，早期监测血清Cys C水平对高血压性脑出血及其颈动脉斑块的评估具有一定的指导意义。

Abstract:
ObjectiveTo investigate the correlation between cystatin C, (Cys C)and hypertensive intracerebral hemorrhage and carotid atherosclerotic plaque.
MethodsOne hundred and fifteen patients with hypertensive cerebral hemorrhage were set as the observation group, and 71 healthy examination people were as the control group.The general information and laboratory inspection between two groups were compared, and the risk factors of cerebral hemorrhage were analyzed using multivariate logistic regression.The observation group was subdivided into the plaque group(57 cases) and nonplaque group(58 cases) according the results of carotid artery ultrasonography, the general information and laboratory inspection between two subgroups were compared, and the risk factors of plaque formation were analyzed using multivariate logistic regression.
ResultsThe levels of serum Cys C and C-reactive protein(CRP) in observation group were significantly higher than those in control group(P < 0.01), and the level of high-density lipoprotein in observation group was significantly lower than that in control group(P < 0.01).Multivariate logistic regression analysis showed that the Cys C and level were the independent risk factors of cerebral hemorrhage.The age, incidence rate of hyperlipidemia and Cys C level in plaque group were significantly higher than those in nonplaque group(P < 0.05 to P < 0.01).Multivariate logistic regression analysis showed that the age and Cys C were the independent risk factors of plaque formation in cerebral hemorrhage patients.
ConclusionsThe serum level of Cys C is closely related to the hypertensive intracerebral hemorrhage and carotid plaque formation, and the early detection of serum Cys C level has certain guiding significance in evaluating the hypertensive intracerebral hemorrhage and carotid plaque.

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