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    血清白细胞介素18、胱抑素C与2型糖尿病下肢血管病变的关系

    Relationships between the levels of interleukin-18 and cystatin C, and arterial intima-media thickness of lower extremity in type 2 diabetic patients

      摘要
    • 摘要:
      目的探讨血清白细胞介素18（IL-18）和胱抑素C（CysC）与2型糖尿病（T2DM）及下肢血管病变的关系及临床价值。
      方法选择112例住院的T2DM病人为A组，同期健康体检者30名为对照组（B组）。彩超测定下肢血管内膜厚度（IMT），A组分为3个亚组A1亚组（IMT < 1.0 mm），A2亚组（1.0 mm ≤ IMT < 1.3 mm），A3亚组（IMT ≥ 1.3 mm）。检测各组空腹血糖（FBG）、糖化血红蛋白（HbA1c）、血脂、肌酐（Cr）、IL-18、CysC等相关指标。
      结果A组血清IL-18、CysC水平均高于B组（P < 0.01）；各亚组的血清IL-18、CysC比较，A3亚组高于A1、A2亚组，A2亚组高于A1亚组（P < 0.05）；多因素多元线性回归结果显示，IL-18、CysC、TC、FPG与下肢IMT呈正相关。
      结论血清IL-18、CysC是IMT的主要影响因素，血清IL-18、CysC与T2DM及下肢IMT存在相关性。

       

      Abstract:
      ObjectiveTo investigate the relationhsips between the levels of interleukin 18 (IL-18) and cystatin C (CysC), and lower extremity vascular lesions in type 2 diabetes mellitus (T2DM) patients, and its clinical significance.
      MethodsOne hundred and twelve patients with T2DM and 30 healthy people were divided into the group A and group B, respectively.According to the arterial intima-media thickness (IMT) of lower extremity vascular detected by ultrasound, the group A was divided into the subgroup A1 (IMT < 1.0 mm), subgroup A2 (1.0 mm ≤ IMT < 1.3 mm) and subgroup A3 (IMT ≥ 1.3 mm).The levels of fasting blood glucose (FBG), glycosylated hemoglobin, blood lipid, creatinine, IL-18 and CysC were measured in all groups.
      ResultsThe levels of serum IL-18 and CysC in group A were higher than those in group B (P < 0.01).The serum levels of IL-18 and CysC in A3 and A2 subgroups were higher than those in A1 and A2 subgroups, and subgroup A1, respectively (P < 0.05).Multivariate linear regression analysis showed that the levels of IL-18, CysC, total cholesterol and FBG were positively correlated with the IMT of lower extremity vascular.
      ConclusionsThe serum levels of IL-18 and CysC are the main influencing factors of IMT, and correlated with the T2DM and IMT of lower limb artery.

       

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