ObjectiveTo investigate the relationship between the levels of small dense low-density lipoprotein (sdLDL), free fatty acid (FFA) and acute coronary syndrome (ACS), and evaluate the correlation of sdLDL, FFA with Gensini score.

MethodsAmong 282 patients suspected by ACS, 92 cases with acute myocardial infarction (AMI), 110 cases with unstable angina pectoris (UAP), 30 case with coronary sclerosis, and 50 cases with normal coronary were divided into the AMI group, UAP group, coronary sclerosis group and normal coronary group according to the results of coronary angiography, respectively.One hundred healthy people were set as the healthy control group.According to the results of Gensini score, the score for ≤ 20 in 81 cases, score for 21-50 in 71 cases and score for>50 in 80 cases were found.The plasma levels of sdLDL, FFA, TC, TG, HDL and LDL in all groups were analyzed.

ResultsThe levels of sdLDL in AMI group and UAP group significantly increased (P < 0.05 to P < 0.01), and the difference of which was not statistically significant between two groups (P>0.05).The levels of FFA in healthy control group, normal coronary group, coronary sclerosis group, UAP group and AMI group gradually increased in turn, and the difference of which was statistically significant (P < 0.05 to P < 0.01).The level of sdLDL was not correlated with Gensini score (P>0.05), and the level of FFA was weakly positively correlated with Gensini score in patients with ACS (P < 0.05).The level of FFA in abnormal coronary patients increased with the increasing of Gensini score, and the difference of which was statistically significant (P < 0.05 to P < 0.01).There was no statistical significance in the level of FFA among Gensini groups in AMI group and UAP group (P>0.05).

ConclusionsThe sdLDL and FFA are closely related to the occurrence of ACS, and FFA may be a potential indicator to judge the severity of coronary artery disease.