高级检索
    徐鹏琛, 孙超. 精索静脉曲张病人血清8-羟基脱氧鸟苷水平的临床价值[J]. 蚌埠医科大学学报, 2019, 44(3): 350-352. DOI: 10.13898/j.cnki.issn.1000-2200.2019.03.020
    引用本文: 徐鹏琛, 孙超. 精索静脉曲张病人血清8-羟基脱氧鸟苷水平的临床价值[J]. 蚌埠医科大学学报, 2019, 44(3): 350-352. DOI: 10.13898/j.cnki.issn.1000-2200.2019.03.020
    shu
    XU Peng-chen, SUN Chao. Clinical significance of the serum level change of 8-hydroxy-2'-deoxyguanosine in patients with varicocele[J]. Journal of Bengbu Medical University, 2019, 44(3): 350-352. DOI: 10.13898/j.cnki.issn.1000-2200.2019.03.020
    Citation: XU Peng-chen, SUN Chao. Clinical significance of the serum level change of 8-hydroxy-2'-deoxyguanosine in patients with varicocele[J]. Journal of Bengbu Medical University, 2019, 44(3): 350-352. DOI: 10.13898/j.cnki.issn.1000-2200.2019.03.020
    shu

    精索静脉曲张病人血清8-羟基脱氧鸟苷水平的临床价值

    Clinical significance of the serum level change of 8-hydroxy-2'-deoxyguanosine in patients with varicocele

      摘要
    • 摘要:
      目的探讨精索静脉曲张（varicocele，VC）病人血清8-羟基脱氧鸟苷（8-hydroxy-2'-deoxyguanosine，8-OHdG）水平的临床价值。
      方法选取行精索静脉高位结扎术治疗的VC病人30例，测量术前和术后3个月的血清8-OHdG水平，比较手术前后的差异，并分析其水平与单、双侧发病、精索静脉宽度的相关。
      结果术前，VC单侧组与双侧组血清8-OHdG水平差异无统计学意义（P>0.05），不同精索静脉宽度病人血清8-OHdG水平差异无统计学意义（P>0.05）。30例病人术后血清8-OHdG水平为（261.64±82.55）pg/mL，较术前的（327.20±101.86）pg/mL明显降低（P < 0.01）。
      结论作为一项氧化应激的指标，血液中8-OHdG水平的升高与VC导致的不育相关，且其水平的降低对于行手术治疗的VC病人预后的判断，有一定的临床意义。

       

      Abstract:
      ObjectiveTo investigate the clinical value of the serum level change of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in varicocele (VC) patients.
      MethodsThe serum levels of 8-OHdG in 30 VC patients treated with high spermatic vein ligation were measured before and after 3 months of surgery.The differences of the serum levels of 8-OHdG between before and after surgery were compared, and the correlations of the level of 8-OHdG with incidence rate of single or bilateral VC and width of spermatic vein were analyzed.
      ResultsBefore surgery, there was no statistically significant in the serum level of 8-OHdG between the VC unilateral group and bilateral group (P>0.05), and there was no statistical significance in the serum levels of 8-OHdG level among patients with different widths of spermatic vein (P>0.05).The postoperative 8-OHdG level(261.64±82.55) pg/mL was significantly lower than that of preoperative level(327.20±101.86) pg/mL in 30 patients (P < 0.01).
      ConclusionsThe serum level of 8-OHdG increasing, an indicator of oxidative stress, is related to the infertility caused by VC, and the level of 8-OHdG decreasing has a certain clinical significance in judging the prognosis of VC patients treated with operation.

       

      • HTML全文
      • 参考文献(12)
      • 相关文章
      • 施引文献
    • 资源附件(0)

    /

    返回文章
    返回