血浆D-二聚体水平与晚期食管鳞癌化疗疗效及预后的相关性研究

谢黎黎; 江启安; 唐文娟

doi:10.13898/j.cnki.issn.1000-2200.2019.04.009

血浆D-二聚体水平与晚期食管鳞癌化疗疗效及预后的相关性研究

Correlation between the plasma level of D-dimer, and chemotherapeutic effect and prognosis in patients with advanced esophageal squamous cell carcinoma

摘要

摘要:
目的探讨血浆D-二聚体水平在晚期食管鳞癌一线姑息化疗疗效及预后判断中的价值。
方法收集91例晚期食管鳞癌病人病例资料，并根据一线姑息化疗前D-二聚体水平分成2组，正常组（≤0.5 μg/mL）和升高组（>0.5 μg/mL）。分析血浆D-二聚体水平与临床特征、化疗疗效和预后的关联。
结果血浆D-二聚体水平与病人血小板水平、纤维蛋白原水平均相关（P < 0.01）。升高组的疾病控制率低于正常组（33.33% vs 69.23%，P < 0.05）。COX多因素分析显示血浆D-二聚体水平是病人预后的独立预测因素（P < 0.01）。
结论血浆D-二聚体水平可能是晚期食管鳞癌化疗疗效的潜在评估标志物，并对预后的判断提供一定依据。

Abstract:
ObjectiveTo investigate the application value of the plasma D-dimer level in the first-line palliative chemotherapy of the advanced esophageal squamous cell carcinoma.
MethodsNinety-one patients with advanced esophageal carcinoma were divided into the normal group(plasma D-dimer level ≤ 0.5 μg/mL) and increasing group(plasma D-dimer level >0.5 μg/mL) according to the plasma D-dimer level before the first-line palliative chemotherapy.The correlations between the plasma D-dimer level, and clinical features, therapeutic effects and prognosis of patients were analyzed.
ResultsThe plasma D-dimer level was correlated with the platelet and fibrinogen levels of patients.The disease control rate in increasing group(33.33%) was lower than that in normal group(69.23%)(P < 0.05).The results of COX multivariate analysis showed that the plasma level of D-dimer was an independent predictive factor of prognosis(P < 0.01).
ConclusionsThe plasma level of D-dimer may be a potential biomarker of the efficacy of the first-line palliative chemotherapy, which can provide certain basis in evaluating prognosis.

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