血浆可溶性晚期糖基化终末产物受体与肺表面活性蛋白A在新生儿急性呼吸窘迫综合征中的表达

李维春; 谢瑞玉; 张克昌

doi:10.13898/j.cnki.issn.1000-2200.2019.04.025

血浆可溶性晚期糖基化终末产物受体与肺表面活性蛋白A在新生儿急性呼吸窘迫综合征中的表达

Plasma expression levels of soluble receptor for advanced glycation end product and pulmonary surfactant protein A in newborn with acute respiratory distress syndrome

摘要

摘要:
目的观察血浆可溶性晚期糖基化终末产物受体（sRAGE）与肺表面活性蛋白A（SP-A）在新生儿急性呼吸窘迫综合征（ARDS）中的表达。
方法收集2015年10月至2017年5月新生儿病房收住的37例ARDS患儿入院时、24 h、72 h的血浆标本，同时收集20例同期入住非呼吸系统疾病患儿3个时间段血浆作为对照组。采用酶联免疫吸附试验测定2组新生儿sRAGE与SP-A水平，并进行统计学分析。
结果ARDS患儿入院时、24 h、72 h的sRAGE和SP-A水平均明显高于对照组（P < 0.01），24 h、72 h的血浆sRAGE和SP-A水平差异有统计学意义（P < 0.01）；对照组患儿血浆sRAGE和SP-A水平入院时、24 h、72 h水平差异无统计学意义（P>0.05）。
结论血浆sRAGE与SP-A在新生儿ARDS患儿高度表达，其水平可能与初始病情有关。

Abstract:
ObjectiveTo observe the plasma expression levels of soluble receptor for advanced glycation end product(sRAGE)and pulmonary surfactant protein A(SP-A) in newborn with acute respiratory distress syndrome(ARDS).
MethodsThe plasma samples of 37 newborns with ARDS from October 2015 to May 2017 were collected after 0 h, 24 h and 72 h of admission, and the plasma samples of 20 newborns without respiratory disease at three time-points were set as the control group at the same time.The plasma levels in two groups were detected using the enzyme linked immunosorbent assay, and the result of which was statistically analyzed.
ResultsThe plasma levels of sRAGE and SP-A in ARDS newborns on admission were significantly higher than those in control group(P < 0.01), and the differences of the plasma levels of sRAGE and SP-A between two groups were statistically significant after 24 h and 72 h of admission(P < 0.01).The differences of the plasma levels of sRAGE and SP-A in control group among three time-points were not statistically significant(P>0.05).
ConclusionsThe plasma levels of sRAGE and SP-A in newborn with ARDS are high, which may be related to the initial condition of disease.

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