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    甲基苯丙胺成瘾者认知功能与渴求的相关研究

    Study on the correlation between cognitive function and craving in methamphetamine addicts

      摘要
    • 摘要:
      目的调查甲基苯丙胺成瘾者的认知功能特征，探讨其与渴求的关系。
      方法抽取安徽某戒毒所的男性甲基苯丙胺成瘾者72名（MA组）和某社区男性居民60名（对照组），采用一般情况调查表和蒙特利尔认知评估量表测量其认知功能和渴求情况，采用视觉模拟标尺法评价MA组渴求情况，并分析MA组认知功能及其与渴求的相关性。
      结果MA组视空间、注意、语言、抽象、延迟回忆5个因子得分和蒙特利尔认知评估量表总分均明显低于对照组（P < 0.01）；2组命名、定向因子得分差异无统计学意义（P>0.05）。相关分析显示，MA组受试者的注意（r=-0.328，P < 0.01）、延迟回忆（r=-0.245，P < 0.05）得分和蒙特利尔认知评估量表总分（r=-0.448，P < 0.01）与渴求均呈负相关关系，而视空间、命名、语言、抽象、定向5个因子和渴求无明显相关关系（P>0.05）。
      结论甲基苯丙胺成瘾者存在广泛的认知功能损害，认知功能与渴求具有相关性，可帮助预测其渴求程度，为通过改善认知功能降低渴求、减少复吸提供了理论依据。

       

      Abstract:
      ObjectiveTo investigate the characteristics of cognitive function in methamphetamine addicts, and explore its relationship with craving.
      MethodsSeventy-two male methamphetamine addicts from a compulsory isolated detoxification center in Anhui Province and sixty male residents from a community were divided into the MA group and control group, respectively.The cognitive function and craving in two groups were measured using general situation questionnaire and Montreal cognitive assessment scale(MoCA).The craving in MA group was evaluated using visual analogue scale, and the correlation of cognitive function with craving in MA group was analyzed.
      ResultsThe visual space score, attention score, language score, abstraction score and delayed recall score, and total score of MoCA in MA group were significantly lower than those in control group(P < 0.01), and the differences of the scores of naming and orientation factors between two groups were not statistically significant(P>0.05).The correlation analysis results showed that the attention score, delayed recall score, and total score of MoCA in MA group were negatively correlated with craving(P < 0.05 and P < 0.01), and there was not significant correlation between visual space, naming, language, abstraction and orientation, and craving(P>0.05).
      ConclusionsThere is extensive cognitive impairment in methamphetamine addicts.Cognitive function is correlated with craving, and can predict the degree of craving, which can provide a theoretical basis for reducing craving and relapse by improving cognitive function.

       

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