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    汤海珍, 韩雪敏, 赵伟, 门秀婷, 赵恒, 钟传飞. 盐酸纳布啡复合枸橼酸舒芬太尼在剖宫产术后镇痛中的应用效果[J]. 蚌埠医科大学学报, 2019, 44(5): 627-631. DOI: 10.13898/j.cnki.issn.1000-2200.2019.05.018
    引用本文: 汤海珍, 韩雪敏, 赵伟, 门秀婷, 赵恒, 钟传飞. 盐酸纳布啡复合枸橼酸舒芬太尼在剖宫产术后镇痛中的应用效果[J]. 蚌埠医科大学学报, 2019, 44(5): 627-631. DOI: 10.13898/j.cnki.issn.1000-2200.2019.05.018
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    TANG Hai-zhen, HAN Xue-min, ZHAO Wei, MEN Xiu-ting, ZHAO Heng, ZHONG Chuan-fei. Effect of the nalbuphine hydrochloride combined with sufentanil citrate on postoperative analgesia after cesarean section[J]. Journal of Bengbu Medical University, 2019, 44(5): 627-631. DOI: 10.13898/j.cnki.issn.1000-2200.2019.05.018
    Citation: TANG Hai-zhen, HAN Xue-min, ZHAO Wei, MEN Xiu-ting, ZHAO Heng, ZHONG Chuan-fei. Effect of the nalbuphine hydrochloride combined with sufentanil citrate on postoperative analgesia after cesarean section[J]. Journal of Bengbu Medical University, 2019, 44(5): 627-631. DOI: 10.13898/j.cnki.issn.1000-2200.2019.05.018
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    盐酸纳布啡复合枸橼酸舒芬太尼在剖宫产术后镇痛中的应用效果

    Effect of the nalbuphine hydrochloride combined with sufentanil citrate on postoperative analgesia after cesarean section

      摘要
    • 摘要:
      目的比较纳布啡复合舒芬太尼与地佐辛复合舒芬太尼用于剖宫产术后静脉镇痛的效果。
      方法选取在腰硬联合麻醉下行剖宫产术的产妇60例，术毕行自控静脉镇痛（PCIA）。随机分为观察组和对照组，各30例。观察组PCIA镇痛采用盐酸纳布啡复合枸橼酸舒芬太尼，对照组采用地佐辛复合枸橼酸舒芬太尼。比较2组产妇术后2、6、12、24、48 h的平均动脉压、心率、脉搏氧饱和度、静息疼痛VAS评分、动态疼痛VAS评分、宫缩痛VAS评分、Ramsay镇静评分，并记录2组PCIA镇痛按压次数及不良反应发生情况。
      结果2组产妇术后2、6、12、24、48 h平均动脉压、心率、脉搏血氧饱和度、静息疼痛VAS评分、动态疼痛VAS评分、Ramsay镇静评分差异均无统计学意义（P>0.05），2组产妇术后2、6、12、24、48 h宫缩痛VAS评分差异均有统计学意义（P < 0.01）。观察组PCIA按压次数明显低于对照组（P < 0.01），不良反应发生率明显低于对照组（P < 0.01）。
      结论盐酸纳布啡复合枸橼酸舒芬太尼对于剖宫产术后镇痛效果良好，尤其是对宫缩痛镇痛效果更佳，术后PCIA镇痛按压次数明显减少，且不良反应发生率低，是一种安全有效的镇痛方式。

       

      Abstract:
      ObjectiveTo compare the effects between nalbuphine combined with sufentanil and dezocine combined with sufentanil on postoperative venous analgesia after caesarean section.
      MethodsSixty parturient women were treated with patient controlled intravenous analgesia(PCIA) after cesarean section under combined lumbar and epidural anesthesia, and randomly divided into the observation group and control group(30 cases each group).The PCIA in observation group and control group was implemented with nalbuphine hydrochloride combined with sufentanil citrate and dezocine combined with sufentanil citrate, respectively.The mean arterial pressure, heart rate, pulse oxygen saturation, quiescent pain VAS score, static dynamic pain VAS score, uterine contractions pain VAS score and Ramsay score between two groups at 2, 6, 12, 24 and 48 h after operation were compared, and the times of PCIA analgesic pressing and adverse reactions in two groups were recorded.
      ResultsAfter 2, 6, 12, 24 and 48 h of operation, the differences of the mean arterial pressure, heart rate, pulse oxygen saturation, quiescent pain VAS score, static dynamic pain VAS score and Ramsay score between two groups were not statistically significant(P>0.05), and the difference of the uterine contractions pain VAS score between two groups was statistically significant(P < 0.01).The time of PCIA analgesic pressing and incidence rate of adverse reaction in observation group were significantly lower than those in control group(P < 0.01).
      ConclusionsNalbuphine hydrochloride combined with sufentanil citrate is a safe and effective analgesic method for cesarean section, especially for uterine contractions pain.The times of the PCIA analgesiac pressing reduce obviously after operation, and the incidence rate of adverse reaction is low.

       

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