ObjectiveTo analyze and compare the choice of high-flux dialysis frequency in maintenance hemodialysis patients and its influence on the detection results of inflammatory cytokines and calcium and phosphorus metabolic indicators.

MethodsFifty-five patients with maintenance hemodialysis and high flux dialysis were randomly selected as the study subjects, According to the random number method, the patients were divided into group A (28 cases, dialysis frequency 4 times per week) and group B(27 cases, dialysis frequency 3 times per week).The levels of serum inflammatory cytokines such as tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), hypersensitive C reactive protein(hs-CRP) and calcium and phosphorus metabolism were measured before and after treatment, the clinical efficacy of the two groups was compared, and the incidence of infection in the two groups was statistically analyzed.The Chinese version of SF-36 developed by Boston Institute of Health(Boston Institute of Health) was used to evaluate the quality of life of the two groups.

ResultsThe levels of TNF-α, IL-6, hs-CRP inflammatory cytokines and serum calcium, phosphorus and calcium-phosphorus product were significantly improved after treatment in two groups, after treatment, all indexes in group A were significantly better than those in group B(P < 0.05 to P < 0.01).The total clinical effective rate and SF-36 score of group A were significantly higher than those of group B(P < 0.01), but there was no significant difference in the incidence of infection between the two groups(P>0.05).

ConclusionsThe increase of high flux dialysis frequency in maintenance hemodialysis patients can effectively improve the level of serum inflammatory cytokines and calcium and phosphorus metabolism, and does not increase the risk of infection.It is of great significance to improve the quality of life of patients.