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    王涛, 江超, 赵萍, 叶明, 陈琳洁. 系统性红斑狼疮病人外周血血清TGF-β1的表达及临床意义[J]. 蚌埠医科大学学报, 2019, 44(7): 868-871, 875. DOI: 10.13898/j.cnki.issn.1000-2200.2019.07.007
    引用本文: 王涛, 江超, 赵萍, 叶明, 陈琳洁. 系统性红斑狼疮病人外周血血清TGF-β1的表达及临床意义[J]. 蚌埠医科大学学报, 2019, 44(7): 868-871, 875. DOI: 10.13898/j.cnki.issn.1000-2200.2019.07.007
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    WANG Tao, JIANG Chao, ZHAO Ping, YE Ming, CHEN Lin-jie. Expression of TGF-β1 in peripheral blood from patients with systemic lupus erythematosus and its clinical significance[J]. Journal of Bengbu Medical University, 2019, 44(7): 868-871, 875. DOI: 10.13898/j.cnki.issn.1000-2200.2019.07.007
    Citation: WANG Tao, JIANG Chao, ZHAO Ping, YE Ming, CHEN Lin-jie. Expression of TGF-β1 in peripheral blood from patients with systemic lupus erythematosus and its clinical significance[J]. Journal of Bengbu Medical University, 2019, 44(7): 868-871, 875. DOI: 10.13898/j.cnki.issn.1000-2200.2019.07.007
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    系统性红斑狼疮病人外周血血清TGF-β1的表达及临床意义

    Expression of TGF-β1 in peripheral blood from patients with systemic lupus erythematosus and its clinical significance

      摘要
    • 摘要:
      目的通过检测转化生长因子β1（TGF-β1）在系统性红斑狼疮（SLE）病人外周血的表达，分析其与临床资料的相关性。
      方法选择56例SLE病人（观察组）和35名健康志愿者（对照组），根据是否合并狼疮肾炎（LN），将56例SLE病人分为合并LN组和无LN组，收集SLE病情活动指数（SLEDAI）等临床资料及实验室检查。采用ELISA方法检测血清TGF-β1，并将检测指标与临床资料及实验室检查指标作相关性分析。
      结果SLE合并LN病人TGF-β1水平低于对照组（P < 0.05）。低活动组SLE病人TGF-β1水平低于高活动组SLE病人（P < 0.05）。观察组病人外周血血清在关节炎受累的病人组中表达较高（P < 0.05），抗U1RNP抗体、抗Sm-D1抗体阳性的病人组中表达较低（P < 0.05）；TGF-β1的水平与SLEDAI、C3、红细胞沉降率、C反应蛋白无相关性（P>0.05），与外周血RBC计数呈正相关（P < 0.05），与24 h尿蛋白定量、血清IgM、球蛋白和天门冬氨酸氨基转移酶的水平呈负相关（P < 0.05）。
      结论TGF-β1具有双向免疫调节的作用，可能参与SLE的肾脏及关节病理。

       

      Abstract:
      ObjectiveTo examine the status and clinical significance of serum transforming growth factor (TGF)-β1 in peripheral blood from patients with systemic lupus erythematosus (SLE).
      MethodsA total of 56 SLE patients and 35 healthy individuals were recruited into this study.According to the presence of lupus nephritis (LN), the SLE patients were divided into two groups:those with LN and those without LN.The serum levels of TGF-β1 were measured using ELISA.The associations between these measurements and SLE disease activity index (SLEDAI) or other laboratory parameters were analyzed by correlation analysis.
      ResultsThe serum TGF-β1 level in the SLE patients with LN was significantly lower than that in the healthy controls (P < 0.05).The serum TGF-β1 level in the SLE patients with lower disease activity was significantly lower than that in patients with higher disease activity (P < 0.05).The serum TGF-β1 level was higher in the patients with arthritis than those without, and was lower in the patients with positive anti-U1RNP or anti-Sm-D1 antibody than those of negative.Correlation analysis showed that the serum TGF-β1 level was not significantly correlated with the SLEDAI score, C3 level, erythrocyte sedimentation rate and C reactive protein (P>0.05), but it was positively correlated with the red blood cell count and negatively correlated with globulin, 24 h urine protein, serum IgM and AST (P < 0.05).
      ConclusionsTGF-β1 has a two-way immunomodulatory effect and may be involved in the pathology of kidney and joint in SLE patients.

       

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